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    FAM177B family with sequence similarity 177 member B [ Homo sapiens (human) ]

    Gene ID: 400823, updated on 17-Sep-2024

    Summary

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    Official Symbol
    FAM177Bprovided by HGNC
    Official Full Name
    family with sequence similarity 177 member Bprovided by HGNC
    Primary source
    HGNC:HGNC:34395
    See related
    Ensembl:ENSG00000197520 AllianceGenome:HGNC:34395
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in stomach (RPKM 8.5), colon (RPKM 2.2) and 6 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FAM177B in Genome Data Viewer
    Location:
    1q41
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (222737202..222751004)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (221970958..221984766)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (222910544..222924346)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_5183 Neighboring gene axin interactor, dorsalization associated Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:222885601-222886515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2582 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_5205 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:222909786-222910327 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1836 Neighboring gene BRO1 domain and CAAX motif containing Neighboring gene uncharacterized LOC105372984 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2583 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1837 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_5246 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1838 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1839 Neighboring gene dispatched RND transporter family member 1 Neighboring gene small nucleolar RNA U13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. Need AC, et al. Hum Mol Genet, 2009 Dec 1. PMID 19734545, Free PMC Article
    2. RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation. Wu SF, et al. Proc Natl Acad Sci U S A, 2020 Jun 23. PMID 32513696, Free PMC Article
    3. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ43505

    General protein information

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    Preferred Names
    protein FAM177B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324080.2 → NP_001311009.1  protein FAM177B

      Status: VALIDATED

      Source sequence(s)
      AL392172
      Consensus CDS
      CCDS1535.2
      UniProtKB/Swiss-Prot
      A6PVY3, Q6ZUN8
      Conserved Domains (1) summary
      pfam14774
      Location:6 → 122
      FAM177; FAM177 family

    2. NM_001394345.1 → NP_001381274.1  protein FAM177B

      Status: VALIDATED

      Source sequence(s)
      AL392172
      Consensus CDS
      CCDS1535.2
      UniProtKB/Swiss-Prot
      A6PVY3, Q6ZUN8
      Related
      ENSP00000414451.2, ENST00000445590.4
      Conserved Domains (1) summary
      pfam14774
      Location:6 → 122
      FAM177; FAM177 family

    3. NM_207468.3 → NP_997351.2  protein FAM177B

      See identical proteins and their annotated locations for NP_997351.2

      Status: VALIDATED

      Source sequence(s)
      AL392172, CA848039
      Consensus CDS
      CCDS1535.2
      UniProtKB/Swiss-Prot
      A6PVY3, Q6ZUN8
      Conserved Domains (1) summary
      pfam14774
      Location:6 → 122
      FAM177; FAM177 family

    RNA

    1. NR_136691.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK125494, AL392172
      Related
      ENST00000391880.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      222737202..222751004
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420602.1 → XP_047276558.1  protein FAM177B isoform X1

    2. XM_017001283.2 → XP_016856772.1  protein FAM177B isoform X3

    3. XM_017001284.2 → XP_016856773.1  protein FAM177B isoform X4

    4. XM_017001281.2 → XP_016856770.1  protein FAM177B isoform X2

      UniProtKB/Swiss-Prot
      A6PVY3, Q6ZUN8
      Conserved Domains (1) summary
      pfam14774
      Location:6 → 122
      FAM177; FAM177 family

    5. XM_017001279.2 → XP_016856768.1  protein FAM177B isoform X2

      UniProtKB/Swiss-Prot
      A6PVY3, Q6ZUN8
      Conserved Domains (1) summary
      pfam14774
      Location:6 → 122
      FAM177; FAM177 family

    6. XM_017001282.2 → XP_016856771.1  protein FAM177B isoform X2

      UniProtKB/Swiss-Prot
      A6PVY3, Q6ZUN8
      Conserved Domains (1) summary
      pfam14774
      Location:6 → 122
      FAM177; FAM177 family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      221970958..221984766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336590.1 → XP_054192565.1  protein FAM177B isoform X1

    2. XM_054336593.1 → XP_054192568.1  protein FAM177B isoform X4

    3. XM_054336592.1 → XP_054192567.1  protein FAM177B isoform X3

    4. XM_054336591.1 → XP_054192566.1  protein FAM177B isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6PVY3.1 GenPept UniProtKB/Swiss-Prot:A6PVY3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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