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    TRIM49D1 tripartite motif containing 49D1 [ Homo sapiens (human) ]

    Gene ID: 399939, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TRIM49D1provided by HGNC
    Official Full Name
    tripartite motif containing 49D1provided by HGNC
    Primary source
    HGNC:HGNC:43973
    See related
    Ensembl:ENSG00000223417 AllianceGenome:HGNC:43973
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRIM49D; TRIM49D2; TRIM49DP; TRIM49D1P; TRIM49D2P
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response; protein ubiquitination; and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See TRIM49D1 in Genome Data Viewer
    Location:
    11q14.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (89911409..89922245, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (89831356..89840458, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (89644577..89655413, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene cell adhesion associated, oncogene regulated pseudogene Neighboring gene MT-ND1 pseudogene 35 Neighboring gene tripartite motif containing 49D2 Neighboring gene cell adhesion associated, oncogene regulated pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of a genomic reservoir for new TRIM genes in primate genomes. Han K, et al. PLoS Genet, 2011 Dec. PMID 22144910, Free PMC Article
    2. Human chromosome 11 DNA sequence and analysis including novel gene identification. Taylor TD, et al. Nature, 2006 Mar 23. PMID 16554811
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tripartite motif-containing protein 49D
    Names
    tripartite motif containing 49D, pseudogene
    tripartite motif containing 49D1, pseudogene
    tripartite motif-containing protein 49-like protein
    tripartite motif-containing protein 49D1
    tripartite motif-containing protein 49D2 pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206627.2 → NP_001193556.1  tripartite motif-containing protein 49D

      See identical proteins and their annotated locations for NP_001193556.1

      Status: VALIDATED

      Source sequence(s)
      AP004607, AP005814
      Consensus CDS
      CCDS60930.1
      UniProtKB/Swiss-Prot
      C9J1S8, I1YAP9
      UniProtKB/TrEMBL
      A0A087WVN7
      Related
      ENSP00000474850.1, ENST00000530311.6
      Conserved Domains (3) summary
      cd16603
      Location:12 → 57
      RING-HC_TRIM43_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM43, TRIM48, TRIM49, TRIM51, TRIM64, TRIM77 and similar proteins
      cd19783
      Location:87 → 139
      Bbox2_TRIM43-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM43, TRIM48, TRIM49, TRIM51, TRIM64, TRIM77 and similar proteins
      cl02614
      Location:285 → 448
      SPRY; SPRY domain

    2. NM_001384911.1 → NP_001371840.1  tripartite motif-containing protein 49D

      Status: VALIDATED

      Source sequence(s)
      AP004607, AP005814
      Consensus CDS
      CCDS60930.1
      UniProtKB/Swiss-Prot
      C9J1S8, I1YAP9
      UniProtKB/TrEMBL
      A0A087WVN7
      Related
      ENSP00000474678.1, ENST00000420869.3
      Conserved Domains (3) summary
      cd16603
      Location:12 → 57
      RING-HC_TRIM43_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM43, TRIM48, TRIM49, TRIM51, TRIM64, TRIM77 and similar proteins
      cd19783
      Location:87 → 139
      Bbox2_TRIM43-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM43, TRIM48, TRIM49, TRIM51, TRIM64, TRIM77 and similar proteins
      cl02614
      Location:285 → 448
      SPRY; SPRY domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      89911409..89922245 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      89831356..89840458 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C9J1S8.1 GenPept UniProtKB/Swiss-Prot:C9J1S8

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