bmp4.L bone morphogenetic protein 4 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: bmp4.L
Official Full Name: bone morphogenetic protein 4 L homeolog
Primary source: Xenbase:XB-GENE-483062
Locus tag: XELAEV_18039648mg
See related: AllianceGenome:Xenbase:XB-GENE-483062
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: bmp4; zyme; DVR-4; bmp-4; bmp2b; ofc11; xbmp4; XBMP-4; bmp2b1; bmp4-a; bmp4-b
Summary: Predicted to enable cytokine activity and growth factor activity. Predicted to act upstream of or within several processes, including BMP signaling pathway; cartilage development; and ossification. Predicted to be located in extracellular space. Is expressed in anatomical system; appendage; mesenchyme; pharyngeal arch; and primary germ layer. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and syndromic microphthalmia 6. Orthologous to human BMP4 (bone morphogenetic protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8L

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8L	NC_054385.1 (85906064..85911997, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	8L	NC_030738.1 (71222237..71227919, complement)

Chromosome 8L - NC_054385.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Osr1/Osr2 normally repress bmp4 expression in the lateral plate mesoderm prior to respiratory specification.
Title: Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus.
The results suggest that DeltaNp63 is an essential gene in early epidermal specification under the control of BMP4.
Title: ΔNp63 is regulated by BMP4 signaling and is required for early epidermal development in Xenopus.
PIAS proteins have differential ability to regulate signals from the growth factors activin, bone morphogenetic protein 4 (BMP4), and Wnt8.
Title: Regulation of early Xenopus development by the PIAS genes.
Data show that PV.1A undergoes combinatorial regulation during early Xenopus development as both the direct target of BMP-4 signaling and as the direct and indirect target of positive and negative regulatory factors.
Title: Direct response elements of BMP within the PV.1A promoter are essential for its transcriptional regulation during early Xenopus development.
Bone morphogenetic protein inhibition is sufficient for neural induction in vivo, and that in the absence of ventral BMPs, Spemann organizer signals are not required for brain formation.
Title: Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation in Xenopus embryos.
Data suggest that the feedback inhibitors BAMBI, SMAD6, and SMAD7 expand the dynamic BMP4 signaling range essential for proper embryonic patterning and reduce interindividual phenotypic and molecular variability in Xenopus embryos.
Title: Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:496641 (e-PCR)
- UniSTS:496641

Bmp4 (e-PCR), detects polymorphism
- UniSTS:496641

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within BMP signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cartilage development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ossification	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bone morphogenetic protein 4

Names: bone morphogenetic protein-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001088032.1 → NP_001081501.1 bone morphogenetic protein 4 precursor

See identical proteins and their annotated locations for NP_001081501.1

Status: PROVISIONAL

Source sequence(s)

AJ005076

UniProtKB/TrEMBL

A0A974C863, O73818, Q6PAF3, Q91703

Conserved Domains (2) summary

smart00204
Location:300 → 400

TGFB; Transforming growth factor-beta (TGF-beta) family

pfam00688
Location:40 → 271

TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054385.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

85906064..85911997 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)