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    STAT5A signal transducer and activator of transcription 5A [ Sus scrofa (pig) ]

    Gene ID: 397550, updated on 11-Apr-2024

    Summary

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    Official Symbol
    STAT5Aprovided by VGNC
    Official Full Name
    signal transducer and activator of transcription 5Aprovided by VGNC
    Primary source
    VGNC:VGNC:99087
    See related
    Ensembl:ENSSSCG00000017402
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Ubiquitous expression in spleen (RPKM 24.8), subcutaneous adipose (RPKM 24.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See STAT5A in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 12 NC_010454.4 (20474221..20498785, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 12 NC_010454.3 (24563982..24581115)

    Chromosome 12 - NC_010454.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110256002 Neighboring gene caveolae associated protein 1 Neighboring gene signal transducer and activator of transcription 3 Neighboring gene signal transducer and activator of transcription 5B Neighboring gene GH3 domain containing Neighboring gene hypocretin neuropeptide precursor Neighboring gene RAB5C, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Assignment of Signal Transducer and Activator of Transcription 5A (STAT5A) gene to porcine chromosome 12p13-->p11 by radiation hybrid panel mapping. Sardina MT, et al. Cytogenet Genome Res, 2006. PMID 16484801
    2. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
    3. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mapped to chromosome 12 by radiation hybrid mapping.
      Title: Assignment of Signal Transducer and Activator of Transcription 5A (STAT5A) gene to porcine chromosome 12p13-->p11 by radiation hybrid panel mapping.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in growth hormone receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to peptide hormone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    signal transducer and activator of transcription 5A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214290.1 → NP_999455.1  signal transducer and activator of transcription 5A

      See identical proteins and their annotated locations for NP_999455.1

      Status: PROVISIONAL

      Source sequence(s)
      AF135122
      UniProtKB/Swiss-Prot
      Q9TUZ1
      UniProtKB/TrEMBL
      A0A8D1JES4, A0A8D2BNV0, E0AD96
      Related
      ENSSSCP00000078841.1, ENSSSCT00000105143.1
      Conserved Domains (4) summary
      pfam01017
      Location:141 → 330
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:332 → 582
      STAT_bind; STAT protein, DNA binding domain
      pfam02865
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain
      cl15255
      Location:573 → 712
      SH2; Src homology 2 (SH2) domain

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010454.4 Reference Sscrofa11.1 Primary Assembly

      Range
      20474221..20498785 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021066247.1 → XP_020921906.1  signal transducer and activator of transcription 5A isoform X1

      UniProtKB/TrEMBL
      A0A0A0MY60, A0A8D1JES4, E0AD96
      Related
      ENSSSCP00000018442.3, ENSSSCT00000018947.4
      Conserved Domains (4) summary
      pfam01017
      Location:141 → 330
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:332 → 582
      STAT_bind; STAT protein, DNA binding domain
      pfam02865
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain
      cl15255
      Location:573 → 712
      SH2; Src homology 2 (SH2) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TUZ1.1 GenPept UniProtKB/Swiss-Prot:Q9TUZ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials