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    THOP1 thimet oligopeptidase 1 [ Sus scrofa (pig) ]

    Gene ID: 397442, updated on 17-Aug-2024

    Summary

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    Official Symbol
    THOP1provided by VGNC
    Official Full Name
    thimet oligopeptidase 1provided by VGNC
    Primary source
    VGNC:VGNC:93961
    See related
    Ensembl:ENSSSCG00000013468
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Ubiquitous expression in liver (RPKM 19.0), ovary (RPKM 16.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See THOP1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 2 NC_010444.4 (75857788..75877430, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 2 NC_010444.3 (76370019..76389661, complement)

    Chromosome 2 - NC_010444.4Genomic Context describing neighboring genes Neighboring gene zinc finger protein 555-like Neighboring gene zinc finger protein 554 Neighboring gene small glutamine rich tetratricopeptide repeat co-chaperone alpha Neighboring gene solute carrier family 39 member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Cloning, amino acid sequence and tissue distribution of porcine thimet oligopeptidase. A comparison with soluble angiotensin-binding protein. Kato A, et al. Eur J Biochem, 1994 Apr 1. PMID 8168506
    2. Targeting of endopeptidase 24.16 to different subcellular compartments by alternative promoter usage. Kato A, et al. J Biol Chem, 1997 Jun 13. PMID 9182559
    3. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thimet oligopeptidase
    Names
    endopeptidase 24.15
    NP_999388.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214223.2 → NP_999388.1  thimet oligopeptidase

      See identical proteins and their annotated locations for NP_999388.1

      Status: PROVISIONAL

      Source sequence(s)
      D21871
      UniProtKB/Swiss-Prot
      P47788
      UniProtKB/TrEMBL
      A0A8D0M518, A0A8D1ZGX2
      Related
      ENSSSCP00000014316.4, ENSSSCT00000014713.5
      Conserved Domains (2) summary
      cd06455
      Location:35 → 675
      M3A_TOP; Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin
      COG0339
      Location:37 → 679
      Dcp; Zn-dependent oligopeptidase [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010444.4 Reference Sscrofa11.1 Primary Assembly

      Range
      75857788..75877430 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47788.2 GenPept UniProtKB/Swiss-Prot:P47788

    Gene LinkOut

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