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    ADAM10 ADAM metallopeptidase domain 10 [ Sus scrofa (pig) ]

    Gene ID: 397345, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ADAM10provided by VGNC
    Official Full Name
    ADAM metallopeptidase domain 10provided by VGNC
    Primary source
    VGNC:VGNC:85061
    See related
    Ensembl:ENSSSCG00000004595
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    ADAM-10
    Expression
    Ubiquitous expression in lung (RPKM 55.5), spleen (RPKM 28.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See ADAM10 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 1 NC_010443.5 (113289480..113407940)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 1 NC_010443.4 (125476146..125527319, complement)

    Chromosome 1 - NC_010443.5Genomic Context describing neighboring genes Neighboring gene 28S ribosomal protein S17, mitochondrial-like Neighboring gene MINDY lysine 48 deubiquitinase 2 Neighboring gene 40S ribosomal protein S15a pseudogene Neighboring gene 40S ribosomal protein S23 pseudogene Neighboring gene uncharacterized LOC102158936 Neighboring gene lipase C, hepatic type Neighboring gene aquaporin 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Antigraft antibody-mediated expression of metalloproteinases on endothelial cells. Differential expression of TIMP-1 and ADAM-10 depends on antibody specificity and isotype. Boulday G, et al. Circ Res, 2001 Mar 2. PMID 11230111
    2. Increase of ADAM10 level in coronary artery in-stent restenosis segments in diabetic minipigs: high ADAM10 expression promoting growth and migration in human vascular smooth muscle cells via Notch 1 and 3. Yang K, et al. PLoS One, 2013. PMID 24386293, Free PMC Article
    3. Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) by articular cartilage chondrocytes. Flannery CR, et al. Matrix Biol, 1999 Jun. PMID 10429942
    4. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. significantly increased expression of ADAM10 in the ISR versus non-ISR segment in diabetic minipigs
      Title: Increase of ADAM10 level in coronary artery in-stent restenosis segments in diabetic minipigs: high ADAM10 expression promoting growth and migration in human vascular smooth muscle cells via Notch 1 and 3.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in membrane protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 10
    Names
    ADAM 10
    a disintegrin and metalloproteinase domain-containing protein 10
    disintegrin-metalloproteinase
    kuzbanian protein homolog
    mammalian disintegrin-metalloprotease
    NP_001124003.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130531.1 → NP_001124003.1  disintegrin and metalloproteinase domain-containing protein 10 precursor

      See identical proteins and their annotated locations for NP_001124003.1

      Status: PROVISIONAL

      Source sequence(s)
      EU753851
      UniProtKB/Swiss-Prot
      B3VKE8, K7GKL8, O77633
      UniProtKB/TrEMBL
      A0A0B8RTY1, A0A8D0K2L7
      Related
      ENSSSCP00000067539.1, ENSSSCT00000088907.2
      Conserved Domains (3) summary
      smart00050
      Location:466 → 545
      DISIN; Homologues of snake disintegrins
      cd04270
      Location:220 → 459
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
      pfam01562
      Location:48 → 141
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010443.5 Reference Sscrofa11.1 Primary Assembly

      Range
      113289480..113407940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O77633.2 GenPept UniProtKB/Swiss-Prot:O77633

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.