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    CASP1 caspase 1, apoptosis-related cysteine peptidase [ Sus scrofa (pig) ]

    Gene ID: 397319, updated on 16-Nov-2023

    Summary

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    Gene symbol
    CASP1
    Gene description
    caspase 1, apoptosis-related cysteine peptidase
    See related
    Ensembl:ENSSSCG00000028711
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Broad expression in lung (RPKM 51.3), spleen (RPKM 20.7) and 6 other tissues See more
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    Genomic context

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    See CASP1 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 9 NC_010451.4 (35188066..35199364, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 9 NC_010451.3 (39210251..39221559, complement)

    Chromosome 9 - NC_010451.4Genomic Context describing neighboring genes Neighboring gene inactive caspase-12-like Neighboring gene caspase-13 Neighboring gene 40S ribosomal protein SA pseudogene Neighboring gene uncharacterized LOC110255428

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Temporal Changes in Caspase-1 and Caspase-8 Activities Following Brain Hypoxia With and Without Src kinase Inhibition in a Piglet Animal Model. Angelis D, et al. Neurochem Res, 2015 Nov. PMID 26342830
    2. The role of SRC kinase in the caspase-1 pathway after hypoxia in the brain of newborn piglets. Angelis D, et al. Neurochem Res, 2014 Nov. PMID 25096901
    3. Endometrial caspase 1 and interleukin-18 expression during the estrous cycle and peri-implantation period of porcine pregnancy and response to early exogenous estrogen administration. Ashworth MD, et al. Reprod Biol Endocrinol, 2010 Apr 9. PMID 20380728, Free PMC Article
    4. Molecular cloning of porcine interleukin-1beta converting enzyme and differential gene expression of IL-1beta converting enzyme, IL-1beta, and IL-18 in porcine alveolar macrophages. Muneta Y, et al. J Interferon Cytokine Res, 1999 Nov. PMID 10574622
    5. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mmediately after hypoxia C8 and C1 follow a similar pattern of increase while long term this appears to dissociate
      Title: Temporal Changes in Caspase-1 and Caspase-8 Activities Following Brain Hypoxia With and Without Src kinase Inhibition in a Piglet Animal Model.
    2. Src kinase mediates hypoxia-induced caspase-1 activation in the cerebral cortex of newborn piglets
      Title: The role of SRC kinase in the caspase-1 pathway after hypoxia in the brain of newborn piglets.
    3. endometrial expression of CASP1 and IL18 associated with pregnancy establishment; alteration of CASP1 and IL18 following premature exposure of uterus to estrogen during early pregnancy may contribute to conceptus loss between Days 15 to 18 of pregnancy
      Title: Endometrial caspase 1 and interleukin-18 expression during the estrous cycle and peri-implantation period of porcine pregnancy and response to early exogenous estrogen administration.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables caspase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    caspase-1
    Names
    CASP-1
    ICE
    IL-1 beta-converting enzyme
    IL-1BC
    caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
    interleukin-1 beta convertase
    interleukin-1 beta converting enzyme
    p45
    NP_999327.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214162.1 → NP_999327.1  caspase-1

      See identical proteins and their annotated locations for NP_999327.1

      Status: PROVISIONAL

      Source sequence(s)
      AB027296
      UniProtKB/Swiss-Prot
      Q9N2I1
      UniProtKB/TrEMBL
      A0A4X1TMD0, A0A8D0Z9X9
      Related
      ENSSSCP00000023919.2, ENSSSCT00000027757.3
      Conserved Domains (2) summary
      smart00115
      Location:153 → 402
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08325
      Location:5 → 84
      CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010451.4 Reference Sscrofa11.1 Primary Assembly

      Range
      35188066..35199364 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N2I1.1 GenPept UniProtKB/Swiss-Prot:Q9N2I1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.