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    C3 complement C3 [ Sus scrofa (pig) ]

    Gene ID: 397072, updated on 17-Aug-2024

    Summary

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    Official Symbol
    C3provided by VGNC
    Official Full Name
    complement C3provided by VGNC
    Primary source
    VGNC:VGNC:99600
    See related
    Ensembl:ENSSSCG00000013551
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    C3d
    Expression
    Biased expression in liver (RPKM 2445.5), mixtures (RPKM 902.5) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 2 NC_010444.4 (72431470..72471622)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 2 NC_010444.3 (72762013..72820437) , (72950572..72957968, complement)

    Chromosome 2 - NC_010444.4Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor interactor 10 Neighboring gene G protein-coupled receptor 108 Neighboring gene TNF superfamily member 14 Neighboring gene cytochrome c-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Quantification of Porcine Complement Activation Fragment C3a by a Neoepitope-Based Enzyme-Linked Immunosorbent Assay. Nilsson PH, et al. Methods Mol Biol, 2021. PMID 33847930
    2. Association of the porcine C3 gene with haemolytic complement activity in the pig. Mekchay S, et al. Genet Sel Evol, 2003. PMID 12927082, Free PMC Article
    3. Molecular characterization of the pig C3 gene and its association with complement activity. Wimmers K, et al. Immunogenetics, 2003 Jan. PMID 12557058
    4. Polymorphic sites in exon 15 and 30 of the porcine C3 gene. Wimmers K, et al. Anim Genet, 2001 Feb. PMID 11419349
    5. Pseudorabies virus glycoprotein III derived from virions and infected cells binds to the third component of complement. Huemer HP, et al. Virus Res, 1992 May. PMID 1320797

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Quantification of Porcine Complement Activation Fragment C3a by a Neoepitope-Based Enzyme-Linked Immunosorbent Assay.
      Title: Quantification of Porcine Complement Activation Fragment C3a by a Neoepitope-Based Enzyme-Linked Immunosorbent Assay.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in complement activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    complement C3
    Names
    complement component C3
    NP_999174.1
    XP_020936478.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214009.1 → NP_999174.1  complement C3 precursor

      See identical proteins and their annotated locations for NP_999174.1

      Status: PROVISIONAL

      Source sequence(s)
      AF154933
      UniProtKB/Swiss-Prot
      O97940, P01025, Q9GKP1
      UniProtKB/TrEMBL
      A0A480J3I1, A0A4X1VPY5
      Related
      ENSSSCP00000077024.1, ENSSSCT00000101941.1
      Conserved Domains (8) summary
      cd00017
      Location:676 → 745
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      cd02896
      Location:994 → 1280
      complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
      cd03583
      Location:1511 → 1659
      NTR_complement_C3; NTR/C345C domain, complement C3 subfamily; The NTR domain found in complement C3 is also known as the C345C domain because it occurs at the C-terminus of complement C3, C4 and C5. Complement C3 plays a pivotal role in the activation of the complement ...
      pfam00207
      Location:768 → 864
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128 → 223
      A2M_N; MG2 domain
      pfam07677
      Location:1396 → 1491
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1049 → 1280
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:456 → 602
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010444.4 Reference Sscrofa11.1 Primary Assembly

      Range
      72431470..72471622
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021080819.1 → XP_020936478.1  complement C3 isoform X1

      UniProtKB/TrEMBL
      A0A480J3I1, A0A4X1VPY5, A0A8D1HCR9
      Conserved Domains (7) summary
      cd00017
      Location:676 → 745
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      cd02896
      Location:994 → 1280
      complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
      cd03583
      Location:1552 → 1700
      NTR_complement_C3; NTR/C345C domain, complement C3 subfamily; The NTR domain found in complement C3 is also known as the C345C domain because it occurs at the C-terminus of complement C3, C4 and C5. Complement C3 plays a pivotal role in the activation of the complement ...
      pfam00207
      Location:768 → 864
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128 → 223
      A2M_N; MG2 domain
      pfam07677
      Location:1437 → 1532
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:454 → 603
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P01025.2 GenPept UniProtKB/Swiss-Prot:P01025

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials