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    IGFBP2 insulin like growth factor binding protein 2 [ Sus scrofa (pig) ]

    Gene ID: 397064, updated on 17-Aug-2024

    Summary

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    Official Symbol
    IGFBP2provided by VGNC
    Official Full Name
    insulin like growth factor binding protein 2provided by VGNC
    Primary source
    VGNC:VGNC:109491
    See related
    Ensembl:ENSSSCG00000035392
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    pIGFBP-2
    Expression
    Biased expression in liver (RPKM 397.2), ovary (RPKM 168.5) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See IGFBP2 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 15 NC_010457.5 (118822092..118850985)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) Unplaced Scaffold NW_003613137.1 (45713..68476, complement)

    Chromosome 15 - NC_010457.5Genomic Context describing neighboring genes Neighboring gene ribosomal protein L37a Neighboring gene uncharacterized LOC110257175 Neighboring gene insulin like growth factor binding protein 5 Neighboring gene transition protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Chromosome location and association of haplotypes of insulin-like growth factor binding protein-2 with production performance in swine. Wang W, et al. Biochem Genet, 2008 Aug. PMID 18427978
    2. Complex mediation of uterine endometrial epithelial cell growth by insulin-like growth factor-II (IGF-II) and IGF-binding protein-2. Badinga L, et al. J Mol Endocrinol, 1999 Dec. PMID 10601973
    3. The unique endometrial expression and genomic organization of the porcine IGFBP-2 gene. Song S, et al. Mol Cell Endocrinol, 1996 Jul 1. PMID 8832579
    4. Identification and NH2-terminal amino acid sequence of three insulin-like growth factor-binding proteins in porcine serum. Coleman ME, et al. Biochem Biophys Res Commun, 1991 Dec 31. PMID 1722398
    5. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest that IGFBP-2 is associated with production performance in pigs.
      Title: Chromosome location and association of haplotypes of insulin-like growth factor binding protein-2 with production performance in swine.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables insulin-like growth factor I binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables insulin-like growth factor II binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    insulin-like growth factor-binding protein 2
    Names
    IBP-2
    IGF-binding protein 2
    IGFBP-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214003.1 → NP_999168.1  insulin-like growth factor-binding protein 2 precursor

      See identical proteins and their annotated locations for NP_999168.1

      Status: PROVISIONAL

      Source sequence(s)
      AF120326
      UniProtKB/Swiss-Prot
      P24853, Q9XSC7
      UniProtKB/TrEMBL
      E3W6T5
      Related
      ENSSSCP00000058079.1, ENSSSCT00000046489.2
      Conserved Domains (2) summary
      smart00121
      Location:33 → 124
      IB; Insulin growth factor-binding protein homologues
      pfam00086
      Location:218 → 297
      Thyroglobulin_1; Thyroglobulin type-1 repeat

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010457.5 Reference Sscrofa11.1 Primary Assembly

      Range
      118822092..118850985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P24853.2 GenPept UniProtKB/Swiss-Prot:P24853

    Gene LinkOut

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