DUOX2 dual oxidase 2 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: DUOX2provided by VGNC
Official Full Name: dual oxidase 2provided by VGNC
Primary source: VGNC:VGNC:103086
See related: Ensembl:ENSSSCG00000004678
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Biased expression in lung (RPKM 11.9), mixtures (RPKM 2.3) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	1	NC_010443.5 (126620468..126641406)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	1	NC_010443.4 (141221502..141241329)

Chromosome 1 - NC_010443.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel recessive c.1226A>G transition of the dual oxidase 2 gene was identified as the causative mutation for a severe congenital hypothyroidism model together with anemia and T lymphopenia which mimics the clinical features of hypothyroid patients
Title: Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis.
Expression along the length of the gastrointestinal tract.
Title: Dual oxidase2 is expressed all along the digestive tract.
the dual oxidase 2 N-terminal region is targeted to the plasma membrane
Title: Targeting of the dual oxidase 2 N-terminal region to the plasma membrane.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info	PubMed
enables peroxidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables superoxide-generating NAD(P)H oxidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info	PubMed
involved_in superoxide anion generation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of NADPH oxidase complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: dual oxidase 2

Names: NADH/NADPH thyroid oxidase p138-tox

NP_999164.2

EC 1.6.3.1

XP_020938217.1

EC 1.6.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213999.2 → NP_999164.2 dual oxidase 2 precursor

See identical proteins and their annotated locations for NP_999164.2

Status: PROVISIONAL

Source sequence(s)

AF547267

UniProtKB/Swiss-Prot

Q8HZK2, Q9TT98

UniProtKB/TrEMBL

A0A4X1VGQ6

Related

ENSSSCP00000049869.2, ENSSSCT00000046180.3

Conserved Domains (6) summary

cd06186
Location:1271 → 1545

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

cd09820
Location:38 → 594

dual_peroxidase_like; Dual oxidase and related animal heme peroxidases

cd00051
Location:824 → 885

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam01794
Location:1085 → 1229

Ferric_reduct; Ferric reductase like transmembrane component

pfam03098
Location:36 → 549

An_peroxidase; Animal haem peroxidase

pfam13499
Location:824 → 884

EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010443.5 Reference Sscrofa11.1 Primary Assembly

Range

126620468..126641406

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021082558.1 → XP_020938217.1 dual oxidase 2 isoform X1

UniProtKB/TrEMBL

A0A287B129, A0A8D0SD24, A0A8D0ZFJ5

Conserved Domains (5) summary

cd06186
Location:1183 → 1457

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

cd09820
Location:1 → 506

dual_peroxidase_like; Dual oxidase and related animal heme peroxidases

cd00051
Location:736 → 797

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:769 → 841

EF-hand_7; EF-hand domain pair

cl26813
Location:995 → 1313

PLN02844; oxidoreductase/ferric-chelate reductase