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    ACO2 aconitase 2 [ Sus scrofa (pig) ]

    Gene ID: 396999, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ACO2provided by VGNC
    Official Full Name
    aconitase 2provided by VGNC
    Primary source
    VGNC:VGNC:97865
    See related
    Ensembl:ENSSSCG00000000064
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Broad expression in heart (RPKM 488.0), psoas major muscle (RPKM 397.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See ACO2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 5 NC_010447.5 (7014383..7071023, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 5 NC_010447.4 (4385951..4443595, complement)

    Chromosome 5 - NC_010447.5Genomic Context describing neighboring genes Neighboring gene phosphomannomutase 1 Neighboring gene uncharacterized LOC110260630 Neighboring gene cold shock domain containing C2 Neighboring gene RNA polymerase III subunit H Neighboring gene uncharacterized LOC110260629 Neighboring gene PHD finger protein 5A Neighboring gene transducer of ERBB2, 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Sites and mechanisms of aconitase inactivation by peroxynitrite: modulation by citrate and glutathione. Han D, et al. Biochemistry, 2005 Sep 13. PMID 16142896
    2. The mechanism of aconitase: 1.8 A resolution crystal structure of the S642a:citrate complex. Lloyd SJ, et al. Protein Sci, 1999 Dec. PMID 10631981, Free PMC Article
    3. The structure of aconitase. Robbins AH, et al. Proteins, 1989. PMID 2798408
    4. Structure of activated aconitase: formation of the [4Fe-4S] cluster in the crystal. Robbins AH, et al. Proc Natl Acad Sci U S A, 1989 May. PMID 2726740, Free PMC Article
    5. Cloning and structural characterization of porcine heart aconitase. Zheng L, et al. J Biol Chem, 1990 Feb 15. PMID 2303429

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables aconitate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aconitate hydratase, mitochondrial
    Names
    citrate hydro-lyase
    heart aconitase
    NP_999119.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213954.1 → NP_999119.1  aconitate hydratase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_999119.1

      Status: PROVISIONAL

      Source sequence(s)
      J05224
      UniProtKB/Swiss-Prot
      P16276
      UniProtKB/TrEMBL
      A0A8W4FBS4
      Related
      ENSSSCP00000000070.4, ENSSSCT00000000070.5
      Conserved Domains (3) summary
      cd01584
      Location:95 → 505
      AcnA_Mitochondrial; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle
      cd01578
      Location:587 → 735
      AcnA_Mitochon_Swivel; Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes ...
      TIGR01340
      Location:45 → 775
      aconitase_mito; aconitate hydratase, mitochondrial

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010447.5 Reference Sscrofa11.1 Primary Assembly

      Range
      7014383..7071023 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16276.1 GenPept UniProtKB/Swiss-Prot:P16276

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