SERPINE1 serpin family E member 1 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: SERPINE1provided by VGNC
Official Full Name: serpin family E member 1provided by VGNC
Primary source: VGNC:VGNC:98310
See related: Ensembl:ENSSSCG00000025698
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: PAI1; PLANH1
Annotation information: Annotation category: partial on reference assembly
Expression: Ubiquitous expression in lung (RPKM 22.3), psoas major muscle (RPKM 18.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	3	NC_010445.4 (8863738..8871572)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	Unplaced Scaffold	NW_003539350.1 (15350..23377)

Chromosome 3 - NC_010445.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In one pig population and in female pigs, SERPINE1 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1) was significantly associated with muscling, growth and fat accretion and in male animals with meat quality.
Title: Association analyses of porcine SERPINE1 reveal sex-specific effects on muscling, growth, fat accretion and meat quality.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of plasminogen activation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of vascular wound healing	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: plasminogen activator inhibitor 1

Names: PAI; PAI-1; endothelial plasminogen activator inhibitor; plasminogen activator inhibitor I; serpin E1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213910.1 → NP_999075.1 plasminogen activator inhibitor 1 precursor

See identical proteins and their annotated locations for NP_999075.1

Status: PROVISIONAL

Source sequence(s)

Y11347

UniProtKB/Swiss-Prot

P79335

UniProtKB/TrEMBL

A0A4X1UD11

Related

ENSSSCP00000026436.4, ENSSSCT00000026956.4

Conserved Domains (1) summary

cl00137
Location:26 → 402

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...