ANXA1 annexin A1 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: ANXA1provided by VGNC
Official Full Name: annexin A1provided by VGNC
Primary source: VGNC:VGNC:103026
See related: Ensembl:ENSSSCG00000005267
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: ANX1
Expression: Broad expression in lung (RPKM 383.5), subcutaneous adipose (RPKM 186.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	1	NC_010443.5 (226414200..226431963)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	1	NC_010443.4 (252989694..253007485)

Chromosome 1 - NC_010443.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest amino acid substitution in ANXA1 (S27E; S27A) at site of post-translational phosphorylation affects protein stability, core domain calcium binding affinity, core domain/N-terminal domain structures, and N-terminal domain orientation.
Title: Molecular dynamic studies on the impact of mutations on the structure, stability, and N-terminal orientation of annexin A1: implications for membrane aggregation.
annexin I is regulated by an anti-apoptotic Bcl-2 protein in Tumor Necrosis Factor-alpha-induced renal apoptotic events
Title: Overexpression of Bcl-2 inhibits nuclear localization of annexin I during tumor necrosis factor-alpha-mediated apoptosis in porcine renal LLC-PK1 cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cadherin binding involved in cell-cell adhesion	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium-dependent phospholipid binding	IEA Inferred from Electronic Annotation more info	PubMed
enables phospholipase A2 inhibitor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	IEA Inferred from Electronic Annotation more info	PubMed
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in alpha-beta T cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in arachidonate secretion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to glucocorticoid stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to vascular endothelial growth factor stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in endocrine pancreas development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in estrous cycle	IEA Inferred from Electronic Annotation more info	PubMed
involved_in gliogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in granulocyte chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in hepatocyte differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in insulin secretion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in keratinocyte differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in myoblast migration involved in skeletal muscle regeneration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of T-helper 2 cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of exocytosis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of phospholipase A2 activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neutrophil clearance	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of T-helper 1 cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell migration involved in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of interleukin-2 production	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of neutrophil apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of prostaglandin biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of vesicle fusion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of wound healing	IEA Inferred from Electronic Annotation more info	PubMed
involved_in prolactin secretion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in prostate gland development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of hormone secretion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of interleukin-1 production	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of leukocyte migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to X-ray	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to interleukin-1	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to peptide hormone	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: annexin A1

Names: annexin I; annexin-1; calpactin II; calpactin-2; chromobindin-9; lipocortin I; p35; phospholipase A2 inhibitory protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.