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    CD46 CD46 molecule, complement regulatory protein [ Sus scrofa (pig) ]

    Gene ID: 396922, updated on 16-Nov-2023

    Summary

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    Gene symbol
    CD46
    Gene description
    CD46 molecule, complement regulatory protein
    See related
    Ensembl:ENSSSCG00000038506
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    MCP
    Expression
    Ubiquitous expression in lung (RPKM 50.4), spleen (RPKM 39.0) and 8 other tissues See more
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    Genomic context

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    See CD46 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 9 NC_010451.4 (135025439..135078910, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 9 NC_010451.3 (148564569..148568279, complement)

    Chromosome 9 - NC_010451.4Genomic Context describing neighboring genes Neighboring gene microRNA mir-29b-2 Neighboring gene microRNA mir-29c Neighboring gene ubiquitin-60S ribosomal protein L40 pseudogene Neighboring gene uncharacterized LOC110255546 Neighboring gene ATP-binding cassette sub-family A member 13 Neighboring gene ATP-binding cassette sub-family A member 13-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Porcine complement regulatory protein CD46 and heparan sulfates are the major factors for classical swine fever virus attachment in vitro. Dräger C, et al. Arch Virol, 2015 Mar. PMID 25559665
    2. Distribution of membrane cofactor protein (MCP/CD46) on pig tissues. Relevance To xenotransplantation. Pérez de la Lastra JM, et al. Immunology, 1999 Sep. PMID 10469245, Free PMC Article
    3. Molecular cloning of a pig homologue of membrane cofactor protein (CD46). Toyomura K, et al. Int Immunol, 1997 Jun. PMID 9199970
    4. Purification and characterization of the pig analogue of human membrane cofactor protein (CD46/MCP). van den Berg CW, et al. J Immunol, 1997 Feb 15. PMID 9029106
    5. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results obtained in this study showed that both porcine CD46 and heparan sulfates play a major role in the initial steps of classical swine fever virus infection.
      Title: Porcine complement regulatory protein CD46 and heparan sulfates are the major factors for classical swine fever virus attachment in vitro.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in negative regulation of complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    membrane cofactor protein
    Names
    CD46 complement regulatory protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213888.1 → NP_999053.1  membrane cofactor protein precursor

      See identical proteins and their annotated locations for NP_999053.1

      Status: PROVISIONAL

      Source sequence(s)
      D70897
      UniProtKB/Swiss-Prot
      O02839
      UniProtKB/TrEMBL
      A0A8D0K471, A0A8D0SBJ0
      Related
      ENSSSCP00000054584.2, ENSSSCT00000063618.3
      Conserved Domains (2) summary
      cd00033
      Location:108 → 167
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd12087
      Location:329 → 359
      TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010451.4 Reference Sscrofa11.1 Primary Assembly

      Range
      135025439..135078910 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021102197.1 → XP_020957856.1  membrane cofactor protein isoform X1

      UniProtKB/TrEMBL
      A0A287BES2, A0A8D1Y191
      Conserved Domains (2) summary
      cd12087
      Location:329 → 359
      TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
      cl27761
      Location:50 → 294
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    2. XM_021102198.1 → XP_020957857.1  membrane cofactor protein isoform X2

      UniProtKB/TrEMBL
      A0A480W2Z4, A0A8D1QYS5
      Conserved Domains (2) summary
      cd12087
      Location:329 → 359
      TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
      cl27761
      Location:50 → 294
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    3. XM_021102199.1 → XP_020957858.1  membrane cofactor protein isoform X3

      UniProtKB/TrEMBL
      A0A024CBD6, A0A287B5I6, A0A8D0NYI1, A0A8D0YQ89, A0A8D1QYC8, A0A8D1Y1A6
      Related
      ENSSSCP00000051363.2, ENSSSCT00000062201.2
      Conserved Domains (2) summary
      cd12087
      Location:329 → 359
      TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
      cl27761
      Location:50 → 294
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O02839.1 GenPept UniProtKB/Swiss-Prot:O02839

    Gene LinkOut

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