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    OLR1 oxidized low density lipoprotein receptor 1 [ Sus scrofa (pig) ]

    Gene ID: 396724, updated on 17-Aug-2024

    Summary

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    Official Symbol
    OLR1provided by VGNC
    Official Full Name
    oxidized low density lipoprotein receptor 1provided by VGNC
    Primary source
    VGNC:VGNC:91038
    See related
    Ensembl:ENSSSCG00000000647
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    LOX1; OLR-1; CLEC8A; PLOX-1
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Broad expression in lung (RPKM 10.8), heart (RPKM 9.5) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See OLR1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 5 NC_010447.5 (61799356..61809691)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 5 NC_010447.4 (64580096..64590442, complement)

    Chromosome 5 - NC_010447.5Genomic Context describing neighboring genes Neighboring gene GABA type A receptor associated protein like 1 Neighboring gene transmembrane protein 52B Neighboring gene C-type lectin domain containing 7A Neighboring gene C-type lectin domain family 1 member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Conserved C-terminal residues within the lectin-like domain of LOX-1 are essential for oxidized low-density-lipoprotein binding. Chen M, et al. Biochem J, 2001 Apr 15. PMID 11284714, Free PMC Article
    2. Selective activation of lectin-like oxidized low-density lipoprotein receptor-1 mediates C-reactive protein-evoked endothelial vasodilator dysfunction in coronary arterioles. Hein TW, et al. Circ Res, 2014 Jan 3. PMID 24141169
    3. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
    4. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables low-density lipoprotein particle receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell death IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in leukocyte cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipoprotein metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    oxidized low-density lipoprotein receptor 1
    Names
    C-type lectin domain family 8 member A
    LOX-1
    lectin-like oxLDL receptor 1
    lectin-like oxidized LDL receptor-1
    lectin-type oxidized LDL receptor 1
    ox-LDL receptor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213805.1 → NP_998970.1  oxidized low-density lipoprotein receptor 1

      See identical proteins and their annotated locations for NP_998970.1

      Status: PROVISIONAL

      Source sequence(s)
      AB018668
      UniProtKB/Swiss-Prot
      Q9TTK7
      UniProtKB/TrEMBL
      A0A076KWW8, A0A0B8RZB2, A0A4X1V3B9, A0A8D0YMJ3, A8CVN6, F1SPE3
      Related
      ENSSSCP00000000683.2, ENSSSCT00000000698.4
      Conserved Domains (1) summary
      cd03593
      Location:144 → 266
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010447.5 Reference Sscrofa11.1 Primary Assembly

      Range
      61799356..61809691
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TTK7.1 GenPept UniProtKB/Swiss-Prot:Q9TTK7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.