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    ESR2 estrogen receptor 2 [ Sus scrofa (pig) ]

    Gene ID: 396697, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ESR2provided by VGNC
    Official Full Name
    estrogen receptor 2provided by VGNC
    Primary source
    VGNC:VGNC:97986
    See related
    Ensembl:ENSSSCG00000005109
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    ER2; ER-beta
    Expression
    Biased expression in ovary (RPKM 3.1) and kidney (RPKM 0.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See ESR2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 1 NC_010443.5 (193823666..193907330)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 1 NC_010443.4 (215715909..215788512)

    Chromosome 1 - NC_010443.5Genomic Context describing neighboring genes Neighboring gene AGBL carboxypeptidase 1 Neighboring gene developmental pluripotency-associated 5 protein-like Neighboring gene 60S ribosomal protein L4 pseudogene Neighboring gene uncharacterized LOC106509133 Neighboring gene spectrin repeat containing nuclear envelope protein 2 Neighboring gene sphingosine-1-phosphate phosphatase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of porcine ovarian estrogen receptor beta isoforms. LaVoie HA, et al. Biol Reprod, 2002 Mar. PMID 11870066
    2. Attenuation of estrogenic effects by dihydrotestosterone in the pig uterus is associated with downregulation of the estrogen receptors. Cárdenas H, et al. Biol Reprod, 2004 Feb. PMID 14522825
    3. Immunolocalization of estrogen receptor beta in the epididymis of mature and immature pigs. Carpino A, et al. Folia Histochem Cytobiol, 2004. PMID 15046395
    4. Association with litter size of new polymorphisms on ESR1 and ESR2 genes in a Chinese-European pig line. Muñoz G, et al. Genet Sel Evol, 2007 Mar-Apr. PMID 17306201, Free PMC Article
    5. Molecular cloning of porcine estrogen receptor-beta complementary DNAs and developmental expression in periimplantation embryos. Kowalski AA, et al. Biol Reprod, 2002 Mar. PMID 11870084

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. There were no statistical differences between the BB genotype and the AB genotype of ESR2 locus in regard to the examined traits. However, a noticeable superiority (P < 0.01) of the BB genotype compared to the homozygous AA genotype, adding almost 2 piglets/litter in TNB and NBA trait, was found.
      Title: Association of BF, RBP4, and ESR2 Genotypes with Litter Size in an Autochthonous Pig Population.
    2. steroid hormones, AhR and estrogen receptor beta are affected by TCDD and genistein in granulosa cells of medium porcine follicles
      Title: The combined effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and the phytoestrogen genistein on steroid hormone secretion, AhR and ERβ expression and the incidence of apoptosis in granulosa cells of medium porcine follicles.
    3. Results suggest that expression levels of protease activated receptors 1 and 2 (PAR-1 and PAR-2) associate with breast cancer outcome in an estrogen receptor (ER)-dependent manner.
      Title: Protease Activated Receptors 1 and 2 Correlate Differently with Breast Cancer Aggressiveness Depending on Tumor ER Status.
    4. results might shed new light on the roles of estrogen receptor 2(ESR2) in spermatogenesis as candidate for boar fertility
      Title: Investigation on association and expression of ESR2 as a candidate gene for boar sperm quality and fertility.
    5. study is the first one to demonstrate the presence of estrogen receptors alpha and beta in the porcine uterus not only at the beginning but also at mid- and late pregnancy
      Title: Expression of oestrogen receptor α and oestrogen receptor β in the uterus of the pregnant swine.
    6. The expression of mRNAs for ERalpha, ERbeta and PR in the sow uterus differed between endometrium and myometrium as well as with stages of the estrous cycle and early pregnancy.
      Title: Messenger RNA levels of estrogen receptors alpha and beta and progesterone receptors in the cyclic and inseminated/early pregnant sow uterus.
    7. ESR2 gene polymorphisms are associated with litter size.
      Title: Detection of novel single-nucleotide polymorphisms (SNPs) in the CYP21 gene and association analysis of two SNPs for CYP21 and ESR2 with litter size in a commercial sow population.
    8. The objective of this study was to search for polymorphisms in the coding region of the estrogen receptors 1 and 2 (ESR1 and ESR2) and to analyze the effects of these variants and the well known intronic ESR1 PvuII polymorphism on litter size.
      Title: Association with litter size of new polymorphisms on ESR1 and ESR2 genes in a Chinese-European pig line.
    9. positive staining for ERalpha in the nuclei of skeletal muscle cells, while the ERbeta stain showed positive signals in nuclei and cytoplasm of skeletal myofibers and myoblasts derived from satellite cells
      Title: Evidence for estrogen receptor alpha and beta expression in skeletal muscle of pigs.
    10. findings suggest that testicular oestrogen receptors alpha and beta may be important factors contributing to onset and maintenance of spermatogenesis in the boar
      Title: Expression of oestrogen receptors alpha and beta and of aromatase in the testis of immature and mature boars.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables nuclear estrogen receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to estradiol stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in estrogen receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    estrogen receptor beta
    Names
    estrogen receptor 2 (ER beta)
    nuclear receptor subfamily 3 group A member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001533.1 → NP_001001533.1  estrogen receptor beta

      See identical proteins and their annotated locations for NP_001001533.1

      Status: PROVISIONAL

      Source sequence(s)
      AF164957
      UniProtKB/Swiss-Prot
      Q9BDW5, Q9XSW2
      UniProtKB/TrEMBL
      A0A4X1WCR1
      Conserved Domains (3) summary
      cd06949
      Location:260 → 494
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:141 → 222
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam12497
      Location:16 → 119
      ERbeta_N; Estrogen receptor beta

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010443.5 Reference Sscrofa11.1 Primary Assembly

      Range
      193823666..193907330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021081294.1 → XP_020936953.1  estrogen receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A4X1WCR1, A0A8D0RLP1, A0A8D1EPG8, F1SRR6
      Conserved Domains (3) summary
      cd06949
      Location:260 → 494
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:141 → 222
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam12497
      Location:12 → 119
      ERbeta_N; Estrogen receptor beta

    2. XM_021081350.1 → XP_020937009.1  estrogen receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A4X1WCR1, A0A8D0RLP1, A0A8D1EPG8, F1SRR6
      Conserved Domains (3) summary
      cd06949
      Location:260 → 494
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:141 → 222
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam12497
      Location:12 → 119
      ERbeta_N; Estrogen receptor beta

    3. XM_021081392.1 → XP_020937051.1  estrogen receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A4X1WCR1, A0A8D0RLP1, A0A8D1EPG8, F1SRR6
      Related
      ENSSSCP00000005491.1, ENSSSCT00000005632.4
      Conserved Domains (3) summary
      cd06949
      Location:260 → 494
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:141 → 222
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam12497
      Location:12 → 119
      ERbeta_N; Estrogen receptor beta
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XSW2.2 GenPept UniProtKB/Swiss-Prot:Q9XSW2

    Gene LinkOut

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    Research Materials