CXCR4 C-X-C motif chemokine receptor 4 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: CXCR4provided by VGNC
Official Full Name: C-X-C motif chemokine receptor 4provided by VGNC
Primary source: VGNC:VGNC:96094
See related: Ensembl:ENSSSCG00000039416
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Broad expression in spleen (RPKM 57.2), lung (RPKM 35.5) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	15	NC_010457.5 (15663652..15666706)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	15	NC_010457.4 (18125415..18128469)

Chromosome 15 - NC_010457.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression and function of the stromal cell-derived factor-1 (SDF-1) and CXC chemokine receptor 4 (CXCR4) in the swine ovarian follicle.
Title: Expression and function of the stromal cell-derived factor-1 (SDF-1) and CXC chemokine receptor 4 (CXCR4) in the swine ovarian follicle.
These results suggest that CXCL12 may be critical for the establishment of pregnancy by regulating trophoblast migration and T cell recruitment into the endometrium during the implantation period in pigs.
Title: Cysteine-X-cysteine motif chemokine ligand 12 and its receptor CXCR4: expression, regulation, and possible function at the maternal-conceptus interface during early pregnancy in pigs.
CXCR4 controls leukocyte mobilization after trauma.
Title: Initial assessment of the role of CXC chemokine receptor 4 after polytrauma.
The new method has shown to be capable of promoting CSCs proliferation and differentiation into cardiomyocytes through activating the SDF-1/CXCR4 axis, while inhibiting myocardial apoptosis , thereby enhancing myocardial regeneration.
Title: Transmyocardial drilling revascularization combined with heparinized bFGF-incorporating stent activates resident cardiac stem cells via SDF-1/CXCR4 axis.
reports transmural and perivascular expression patterns of chemokines CCL2 and CXCL2 and of chemokine receptors CCR2, CCR5, and CXCR4 following coronary angioplasty
Title: Sequential patterns of chemokine- and chemokine receptor-synthesis following vessel wall injury in porcine coronary arteries.

Submit: New GeneRIF Correction

General gene information

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Markers

CXCR4 (e-PCR)
- UniSTS:480008

PMC109444P3 (e-PCR)
- UniSTS:270168

CXCR4 (e-PCR)
- UniSTS:266378

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables chemokine receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables cytokine binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in brain development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neurogenesis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: C-X-C chemokine receptor type 4

Names: CXC-R4; CXCR-4; chemokine (C-X-C motif) receptor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213773.1 → NP_998938.1 C-X-C chemokine receptor type 4

See identical proteins and their annotated locations for NP_998938.1

Status: PROVISIONAL

Source sequence(s)

AB116560

UniProtKB/Swiss-Prot

Q764M9

Related

ENSSSCP00000058444.1, ENSSSCT00000064385.3

Conserved Domains (2) summary

pfam00001
Location:56 → 303

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam12109
Location:6 → 39

CXCR4_N; CXCR4 Chemokine receptor N terminal