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    HBBA hemoglobin subunit epsilon 1 [ Gallus gallus (chicken) ]

    Gene ID: 396485, updated on 17-Aug-2024

    Summary

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    Symbol
    HBBAprovided by CGNC
    Full Name
    hemoglobin subunit epsilon 1provided by CGNC
    Primary source
    CGNC:49831
    See related
    Ensembl:ENSGALG00010003868
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    HBG2; HBB-A
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    Genomic context

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    See HBBA in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (196004356..196005887, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (195874870..195876401, complement)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor, family 51, subfamily M, member 1 Neighboring gene hemoglobin subunit epsilon Neighboring gene hemoglobin subunit epsilon 1 Neighboring gene hemoglobin beta, subunit rho

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. BetaA, the major beta globin in definitive red blood cells, is present from the onset of primitive erythropoiesis in chicken. Alev C, et al. Dev Dyn, 2008 Apr. PMID 18351667
    2. Analysis of the adult chicken beta-globin gene. Nucleotide sequence of the locus, microheterogeneity at the 5'-end of beta-globin mRNA, and aberrant nuclear RNA species. Dolan M, et al. J Biol Chem, 1983 Mar 25. PMID 6833240
    3. Cloning of chicken globin cDNA in bacterial plasmids. Padayatty J, et al. Gene, 1981 May. PMID 6266925
    4. 5' Domain and nucleotide sequence of an adult chicken chromosomal beta-globin gene. Day LE, et al. Biochemistry, 1981 Apr 14. PMID 6263308
    5. Targeted deletion of the chicken beta-globin regulatory elements reveals a cooperative gene silencing activity. Wang J, et al. J Biol Chem, 2005 Jun 17. PMID 15824098

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Flanking a transgenic construct by chicken HS4 insulation sequences from beta globin leads to overall increase in the expression of nkx2.5:mRFP.
      Title: Chicken β-globin insulators fail to shield the nkx2.5 promoter from integration site effects in zebrafish.
    2. Data show that loss of boundary function leads to the sequential spreading of H3K9me2, H3K9me3, and H4K20me3 over the entire 50 kb FOLR1 and beta-globin region and silencing of FOLR1 expression.
      Title: Histone crosstalk directed by H2B ubiquitination is required for chromatin boundary integrity.
    3. Data suggest that betaA locus is active from the onset of primitive erythropoiesis and that beta globin switching during development may reflect a change in relative transcript abundance rather than a strict on/off switch in gene activation.
      Title: BetaA, the major beta globin in definitive red blood cells, is present from the onset of primitive erythropoiesis in chicken.
    4. The Beta-globuin insulator confers copy-number-dependent transgene expression and can increase transgene expression from weak regulatory elements
      Title: Chicken beta-globin insulator overcomes variegation of transgenes in Xenopus embryos.
    5. a domain of active chromatin is formed by spreading from a beta-globin enhancer to a target gene and can be blocked by a nucleosome-free gap in an insulato
      Title: Enhancer blocking by chicken beta-globin 5'-HS4: role of enhancer strength and insulator nucleosome depletion.
    6. a DNA sequence element, HS4, at the 5' end of the beta-globin locus, contains a binding site for CTCF that is necessary and sufficient for insulator action
      Title: The 5'-HS4 chicken beta-globin insulator is a CTCF-dependent nuclear matrix-associated element.
    7. regulatory elements of chicken beta-globin function as part of a common silencing pathway
      Title: Targeted deletion of the chicken beta-globin regulatory elements reveals a cooperative gene silencing activity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables haptoglobin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables organic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables oxygen binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables oxygen carrier activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hydrogen peroxide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in oxygen transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in blood microparticle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of haptoglobin-hemoglobin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of hemoglobin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hemoglobin subunit beta
    Names
    beta-A globin
    hemoglobin beta, subunit A
    hemoglobin, gamma G

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205489.3 → NP_990820.1  hemoglobin subunit beta

      See identical proteins and their annotated locations for NP_990820.1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000032
      UniProtKB/Swiss-Prot
      P02112, Q90594, Q90863, Q90938
      Related
      ENSGALP00010005277.1, ENSGALT00010008945.1
      Conserved Domains (1) summary
      cd08925
      Location:7 → 146
      Hb-beta_like; Hemoglobin beta, gamma, delta, epsilon, and related Hb subunits

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      196004356..196005887 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      195874870..195876401 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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