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    HMOX1 heme oxygenase 1 [ Gallus gallus (chicken) ]

    Gene ID: 396287, updated on 10-Oct-2024

    Summary

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    Symbol
    HMOX1provided by CGNC
    Full Name
    heme oxygenase 1provided by CGNC
    Primary source
    CGNC:49737
    See related
    Ensembl:ENSGALG00010015155
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    HO-1
    Orthologs
    human mouse all
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    Genomic context

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    See HMOX1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (52145778..52151916, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (52440203..52446343, complement)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112533487 Neighboring gene RASD family member 2 Neighboring gene minichromosome maintenance complex component 5 Neighboring gene target of myb1 membrane trafficking protein Neighboring gene HMG-box containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Down-regulation of cellular protein heme oxygenase-1 inhibits proliferation of avian influenza virus H9N2 in chicken oviduct epithelial cells. Qi X, et al. J Gen Virol, 2018 Jan. PMID 29219807
    2. Expression pattern of heme oxygenase 1 gene and hypoxic adaptation in chicken embryos. Gou W, et al. Comp Biochem Physiol B Biochem Mol Biol, 2014 Aug. PMID 24947210
    3. Expression and activity analysis reveal that heme oxygenase (decycling) 1 is associated with blue egg formation. Wang ZP, et al. Poult Sci, 2011 Apr. PMID 21406370
    4. Molecular cloning, characterization, and expression of the chicken heme oxygenase-1 gene in transfected primary cultures of chick embryo liver cells. Lu TH, et al. Gene, 1998 Jan 30. PMID 9511760
    5. Purification and characterization of heme oxygenase from chick liver. Comparison of the avian and mammalian enzymes. Bonkovsky HL, et al. Eur J Biochem, 1990 Apr 20. PMID 2158889

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Down-regulation of cellular heme oxygenase-1 inhibits proliferation of avian influenza virus H9N2 in chicken oviduct epithelial cells.
      Title: Down-regulation of cellular protein heme oxygenase-1 inhibits proliferation of avian influenza virus H9N2 in chicken oviduct epithelial cells.
    2. Tibet chicken has higher HO-1 expression on D19 under hypoxic incubation and has two SNPs with different frequency distributions from other chicken breeds, a way for Tibet chicken hereditary adaptation to hypoxia during embryonic development.
      Title: Expression pattern of heme oxygenase 1 gene and hypoxic adaptation in chicken embryos.
    3. This study found that tissue hypoxia is likely a normal component of embryonic development in the chicken based on the upregulation of hypoxia response genes.
      Title: The expression patterns of hypoxia-inducing factor subunit alpha-1, heme oxygenase, hypoxia upregulated protein 1, and cardiac troponin T during development of the chicken heart.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables heme oxygenase (decyclizing) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heme catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in heme oxidation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heme oxygenase 1
    Names
    heme oxygenase (decycling) 1
    NP_990675.2
    XP_046777464.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205344.2 → NP_990675.2  heme oxygenase 1

      Status: VALIDATED

      Source sequence(s)
      AM064663, BI390545, BU123222, BX269217, CF251749, HM237181
      Related
      ENSGALP00010021271.1, ENSGALT00010036522.1

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      52145778..52151916 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046921508.1 → XP_046777464.1  heme oxygenase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YRE4
      Related
      ENSGALP00010021265.1, ENSGALT00010036516.1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      52440203..52446343 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14791.2 GenPept UniProtKB/Swiss-Prot:P14791

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials