OVAL ovalbumin (SERPINB14) [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: OVALprovided by CGNC
Official Full Name: ovalbumin (SERPINB14)provided by CGNC
Primary source: CGNC:49631
See related: Ensembl:ENSGALG00010011679
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: OVA; SERPINB14
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Genomic context

Location:: chromosome: 2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	2	NC_052533.1 (67424691..67432269, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	2	NC_052574.1 (67397956..67405533, complement)

Chromosome 2 - NC_052533.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Role of Ovalbumin in Manganese Homeostasis during Chick Embryogenesis: An EPR Spectroscopic Study.
Title: The Role of Ovalbumin in Manganese Homeostasis during Chick Embryogenesis: An EPR Spectroscopic Study.
Cloning, characterisation and expression of the SERPINB14 gene, and association of promoter polymorphisms with egg quality traits in layer chicken.
Title: Cloning, characterisation and expression of the SERPINB14 gene, and association of promoter polymorphisms with egg quality traits in layer chicken.
Cracking Proteoform Complexity of Ovalbumin with Anion-Exchange Chromatography-High-Resolution Mass Spectrometry under Native Conditions.
Title: Cracking Proteoform Complexity of Ovalbumin with Anion-Exchange Chromatography-High-Resolution Mass Spectrometry under Native Conditions.
120A and C30/73/120A mutants formed no SS form, in contrast to C73/120A as a control. Thus, we concluded that Cys30 participates in the correct folding of OVA, and that its SS bond (Cys11-Cys30) is transiently generated during the early folding stage to avoid misfolding, and then the native SS form of OVA is regenerated through SH-SS exchanges.
Title: Participation of cysteine 30 residue in the folding process of ovalbumin evaluated in a refolding experiment using cysteine mutants.
Data show that both ovalbumin and ovomucoid were efficiently mutagenized in cultured primordial germ cells (PGCs) by CRISPR/Cas9 system.
Title: Targeted mutagenesis in chicken using CRISPR/Cas9 system.
Data show that both green and red light wavelengths induce structural changes in ovalbumin.
Title: Effects of green and red light in βL-crystallin and ovalbumin.
found that ovalbumin packs into a bicontinuous structure with a significant void space and that ovalbumin is highly ordered within the dense network
Title: Local Crystalline Structure in an Amorphous Protein Dense Phase.
Cluster analysis revealed a first group of proteins related to mineralization and mainly present at the onset of calcification including OVOT, OVAL, OC-17, and two novel calcium binding proteins (EDIL3, MFGE8).
Title: Quantitative proteomics and bioinformatic analysis provide new insight into protein function during avian eggshell biomineralization.
Secondary and tertiary structures of OVA were characterised to show the relationship between potential allergenicity and the conformation of OVA after heating and glycation.
Title: Conformation affects the potential allergenicity of ovalbumin after heating and glycation.
Inhalation tolerance limits aeroallergen OVA peptide capture by airway mucosal dendritic cell subsets via a mechanism of bone marrow suppression of dendritic cell precursor function coupled with reduced antigen availability in vivo at the airway mucosa.
Title: Restricted aeroallergen access to airway mucosal dendritic cells in vivo limits allergen-specific CD4+ T cell proliferation during the induction of inhalation tolerance.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: ovalbumin

Names: allergen Gal d II; clade (ovalbumin); egg albumin; member 14; plakalbumin; serpin peptidase inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205152.3 → NP_990483.2 ovalbumin precursor

Status: PROVISIONAL

Source sequence(s)

JAENSK010000040

UniProtKB/Swiss-Prot

P01012, Q804A4, Q90741

UniProtKB/TrEMBL

A0A2H4Y7T3, A0A2H4Y7T9, A0A2H4Y7U6, A0A2H4Y7U9, A0A2H4Y7W2, A0A2H4Y7W9, A0A2H4Y7X9, A0A2H4Y7Z3, A0A2H4Y838, A0A2H4Y850, A0A2H4Y868, A0A2H4Y889, A0A2H4Y890, A0A2H4Y896, A0A2H4Y8A4, A0A2H4Y8A9, A0A2H4Y8B0, A0A2H4Y8E5, A0A2H4Y8E7, A0A2H4Y8J6, A0A2H4Y8J8, A0A2H4Y8K8, A0A2H4Y8M4, A0A2H4Y8P3, A0A411G5W6

Related

ENSGALP00010016033.1, ENSGALT00010027940.1

Conserved Domains (1) summary

cd02059
Location:2 → 386

serpinB14_OVA; serpin family B member 14, ovalbumin

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

67424691..67432269 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

67397956..67405533 complement

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GenBank, FASTA, Sequence Viewer (Graphics)