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    PSAP prosaposin [ Gallus gallus (chicken) ]

    Gene ID: 395602, updated on 10-Oct-2024

    Summary

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    Official Symbol
    PSAPprovided by CGNC
    Official Full Name
    prosaposinprovided by CGNC
    Primary source
    CGNC:49395
    See related
    Ensembl:ENSGALG00010020103
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
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    Genomic context

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    See PSAP in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 6 NC_052537.1 (12654045..12674176, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 6 NC_052578.1 (12699927..12720115, complement)

    Chromosome 6 - NC_052537.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 29 member 3 Neighboring gene cadherin related 23 Neighboring gene V-set immunoregulatory receptor Neighboring gene proactivator polypeptide-like Neighboring gene uncharacterized LOC121111122 Neighboring gene carbohydrate sulfotransferase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning, expression and map assignment of chicken prosaposin. Azuma N, et al. Biochem J, 1998 Feb 15. PMID 9461526, Free PMC Article
    2. Expression patterns of prosaposin and its receptors, G protein-coupled receptor (GPR) 37 and GPR37L1 mRNAs, in the chick inner ear. Sohel MSH, et al. Cell Tissue Res, 2023 May. PMID 36750499
    3. Conservation of expression and alternative splicing in the prosaposin gene. Cohen T, et al. Brain Res Mol Brain Res, 2004 Oct 22. PMID 15469878
    4. Non-coding RNAs revealed during identification of genes involved in chicken immune responses. Ahanda ML, et al. Immunogenetics, 2009 Jan. PMID 19009289
    5. Transcriptome analysis for the chicken based on 19,626 finished cDNA sequences and 485,337 expressed sequence tags. Hubbard SJ, et al. Genome Res, 2005 Jan. PMID 15590942, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression patterns of prosaposin and its receptors, G protein-coupled receptor (GPR) 37 and GPR37L1 mRNAs, in the chick inner ear.
      Title: Expression patterns of prosaposin and its receptors, G protein-coupled receptor (GPR) 37 and GPR37L1 mRNAs, in the chick inner ear.
    2. Data show that there is evolutionary conservation of the prosaposin structure and alternative splicing, and in expression in the mouse and chick developing brain.
      Title: Conservation of expression and alternative splicing in the prosaposin gene.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prosaposin
    Names
    proactivator polypeptide

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204811.3 → NP_990142.2  prosaposin precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000230
      UniProtKB/Swiss-Prot
      O13035
      Conserved Domains (2) summary
      smart00162
      Location:22 → 55
      SAPA; Saposin/surfactant protein-B A-type DOMAIN
      smart00741
      Location:402 → 476
      SapB; Saposin (B) Domains

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      12654045..12674176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015288195.4 → XP_015143681.2  prosaposin isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZBR2
      Related
      ENSGALP00010028658.1, ENSGALT00010048567.1
      Conserved Domains (2) summary
      smart00162
      Location:22 → 55
      SAPA; Saposin/surfactant protein-B A-type DOMAIN
      smart00741
      Location:399 → 473
      SapB; Saposin (B) Domains

    2. XM_015288194.4 → XP_015143680.2  prosaposin isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZBR2, A0A8V0ZD67
      Related
      ENSGALP00010028655.1, ENSGALT00010048564.1
      Conserved Domains (2) summary
      smart00162
      Location:22 → 55
      SAPA; Saposin/surfactant protein-B A-type DOMAIN
      smart00741
      Location:422 → 496
      SapB; Saposin (B) Domains

    3. XM_015288193.4 → XP_015143679.2  prosaposin isoform X1

      UniProtKB/Swiss-Prot
      O13035
      UniProtKB/TrEMBL
      A0A8V0Z5X2
      Related
      ENSGALP00010028657.1, ENSGALT00010048566.1
      Conserved Domains (2) summary
      smart00162
      Location:22 → 55
      SAPA; Saposin/surfactant protein-B A-type DOMAIN
      smart00741
      Location:425 → 499
      SapB; Saposin (B) Domains

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      12699927..12720115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046919905.1 → XP_046775861.1  prosaposin isoform X3

    2. XM_046919904.1 → XP_046775860.1  prosaposin isoform X2

    3. XM_046919903.1 → XP_046775859.1  prosaposin isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O13035.1 GenPept UniProtKB/Swiss-Prot:O13035

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials