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    TH tyrosine hydroxylase [ Gallus gallus (chicken) ]

    Gene ID: 395592, updated on 17-Aug-2024

    Summary

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    Symbol
    THprovided by CGNC
    Full Name
    tyrosine hydroxylaseprovided by CGNC
    Primary source
    CGNC:4940
    See related
    Ensembl:ENSGALG00010026940
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (13321407..13337838)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (13289874..13306274)

    Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene tetraspanin 32 Neighboring gene microRNA 6642 Neighboring gene achaete-scute family bHLH transcription factor 2 Neighboring gene uncharacterized LOC124418032 Neighboring gene insulin Neighboring gene insulin like growth factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hypothalamic vasotocin and tyrosine hydroxylase levels following maternal care and selection for low mortality in laying hens. Hewlett SE, et al. BMC Vet Res, 2014 Jul 31. PMID 25080935, Free PMC Article
    2. Effects of maternal care and selection for low mortality on tyrosine hydroxylase concentrations and cell soma size in hippocampus and nidopallium caudolaterale in adult laying hen. Nordquist RE, et al. J Anim Sci, 2013 Jan. PMID 23048145
    3. Tyrosine hydroxylase is expressed during early heart development and is required for cardiac chamber formation. López-Sánchez C, et al. Cardiovasc Res, 2010 Oct 1. PMID 20525643
    4. The expression of tyrosine hydroxylase and the transcription factors cPhox-2 and Cash-1: evidence for distinct inductive steps in the differentiation of chick sympathetic precursor cells. Ernsberger U, et al. Mech Dev, 1995 Jul. PMID 7577670
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The effect of foster hen rearing on the two genetic lines and their hypothalamic morphology, and the role of tyrosine hydroxylase and vasotocin levels in feather pecking, are reported.
      Title: Hypothalamic vasotocin and tyrosine hydroxylase levels following maternal care and selection for low mortality in laying hens.
    2. These results indicate that morphological changes in brain induced in very early life can be detected in adult hens, and that genetic selection against mortality due to cannibalism impacts tyrosine hydroxylase in the brain of laying hens.
      Title: Effects of maternal care and selection for low mortality on tyrosine hydroxylase concentrations and cell soma size in hippocampus and nidopallium caudolaterale in adult laying hen.
    3. TH is expressed in a dynamic pattern during the primitive heart tube formation. TH induces cardiac differentiation in vivo and it is a key regulator of the heart patterning, conferring atriogenic identity.
      Title: Tyrosine hydroxylase is expressed during early heart development and is required for cardiac chamber formation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables tyrosine 3-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dopamine biosynthetic process from tyrosine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine 3-monooxygenase
    NP_990136.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204805.2 → NP_990136.1  tyrosine 3-monooxygenase

      See identical proteins and their annotated locations for NP_990136.1

      Status: VALIDATED

      Source sequence(s)
      AJ251387
      UniProtKB/TrEMBL
      A0A8V1A973, Q9PU40
      Related
      ENSGALP00010039771.1, ENSGALT00010065339.1
      Conserved Domains (4) summary
      TIGR01269
      Location:38 → 490
      Tyr_3_monoox; tyrosine 3-monooxygenase, tetrameric
      pfam00351
      Location:159 → 488
      Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
      pfam12549
      Location:2 → 26
      TOH_N; Tyrosine hydroxylase N terminal
      cl09141
      Location:38 → 153
      ACT; ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      13321407..13337838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      13289874..13306274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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