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    OR8B3 olfactory receptor family 8 subfamily B member 3 [ Homo sapiens (human) ]

    Gene ID: 390271, updated on 2-Nov-2024

    Summary

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    Official Symbol
    OR8B3provided by HGNC
    Official Full Name
    olfactory receptor family 8 subfamily B member 3provided by HGNC
    Primary source
    HGNC:HGNC:8472
    See related
    Ensembl:ENSG00000284609 AllianceGenome:HGNC:8472
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR11-311
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    See OR8B3 in Genome Data Viewer
    Location:
    11q24.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (124395534..124409807, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (124424199..124438480, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (124265430..124268920, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 8 subfamily B member 1 pseudogene Neighboring gene olfactory receptor family 8 subfamily C member 1 pseudogene Neighboring gene olfactory receptor family 8 subfamily B member 2 Neighboring gene uncharacterized LOC107984404 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:124275254-124276453 Neighboring gene olfactory receptor family 8 subfamily X member 1 pseudogene Neighboring gene olfactory receptor family 8 subfamily B member 4 Neighboring gene olfactory receptor family 8 subfamily B member 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables odorant binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of smell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    olfactory receptor 8B3
    Names
    olfactory receptor OR11-311

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005467.2 → NP_001005467.1  olfactory receptor 8B3

      See identical proteins and their annotated locations for NP_001005467.1

      Status: VALIDATED

      Source sequence(s)
      AP001804
      Consensus CDS
      CCDS31709.1
      UniProtKB/Swiss-Prot
      Q6IFQ8, Q8NGG8, Q8NGH1
      UniProtKB/TrEMBL
      A0A126GWT8
      Related
      ENSP00000493120.1, ENST00000641139.1
      Conserved Domains (2) summary
      pfam00001
      Location:41 → 289
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:31 → 304
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      124395534..124409807 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017716.2 → XP_016873205.1  olfactory receptor 8B3 isoform X1

      UniProtKB/Swiss-Prot
      Q6IFQ8, Q8NGG8, Q8NGH1
      UniProtKB/TrEMBL
      A0A126GWT8
      Conserved Domains (2) summary
      pfam00001
      Location:41 → 289
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:31 → 304
      7tm_4; Olfactory receptor

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      124424199..124438480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368743.1 → XP_054224718.1  olfactory receptor 8B3 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NGG8.3 GenPept UniProtKB/Swiss-Prot:Q8NGG8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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