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    ZNF324B zinc finger protein 324B [ Homo sapiens (human) ]

    Gene ID: 388569, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ZNF324Bprovided by HGNC
    Official Full Name
    zinc finger protein 324Bprovided by HGNC
    Primary source
    HGNC:HGNC:33107
    See related
    Ensembl:ENSG00000249471 AllianceGenome:HGNC:33107
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in spleen (RPKM 1.5), kidney (RPKM 1.4) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF324B in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58418396..58457833)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61514353..61553798)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58962989..58969200)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15195 Neighboring gene long intergenic non-protein coding RNA 2560 Neighboring gene ZNF584 divergent transcript Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58919203-58919848 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11082 Neighboring gene zinc finger protein 584 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58951186-58951696 Neighboring gene zinc finger protein 132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58952208-58952717 Neighboring gene ZNF132 divergent transcript Neighboring gene zinc finger protein 250 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr19:58962695-58963021 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11083 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58978178-58978794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58978795-58979409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15199 Neighboring gene zinc finger protein 324 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15201 Neighboring gene Sharpr-MPRA regulatory region 9894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15203 Neighboring gene uncharacterized LOC112268251 Neighboring gene zinc finger protein 446 Neighboring gene RNA, U6 small nuclear 1337, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nozawa RS, et al. Nat Cell Biol, 2010 Jul. PMID 20562864
    2. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
    3. A dual-activity topoisomerase complex regulates mRNA translation and turnover. Su S, et al. Nucleic Acids Res, 2022 Jul 8. PMID 35748872, Free PMC Article
    4. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article
    5. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • FLJ45850

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 324B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207395.3 → NP_997278.2  zinc finger protein 324B

      See identical proteins and their annotated locations for NP_997278.2

      Status: VALIDATED

      Source sequence(s)
      AC012313, AK127750, BC140881, BM714371
      Consensus CDS
      CCDS33138.1
      UniProtKB/Swiss-Prot
      B2RTZ6, Q6AW86, Q6ZMX8, Q6ZS42
      Related
      ENSP00000337473.3, ENST00000336614.9
      Conserved Domains (3) summary
      smart00349
      Location:1 → 61
      KRAB; krueppel associated box
      COG5048
      Location:268 → 499
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259 → 279
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      58418396..58457833
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438807.1 → XP_047294763.1  zinc finger protein 324B isoform X2

    2. XM_047438806.1 → XP_047294762.1  zinc finger protein 324B isoform X1

      UniProtKB/Swiss-Prot
      B2RTZ6, Q6AW86, Q6ZMX8, Q6ZS42

    3. XM_005258918.5 → XP_005258975.1  zinc finger protein 324B isoform X1

      See identical proteins and their annotated locations for XP_005258975.1

      UniProtKB/Swiss-Prot
      B2RTZ6, Q6AW86, Q6ZMX8, Q6ZS42
      Conserved Domains (3) summary
      smart00349
      Location:1 → 61
      KRAB; krueppel associated box
      COG5048
      Location:268 → 499
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259 → 279
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_005258915.5 → XP_005258972.1  zinc finger protein 324B isoform X1

      See identical proteins and their annotated locations for XP_005258972.1

      UniProtKB/Swiss-Prot
      B2RTZ6, Q6AW86, Q6ZMX8, Q6ZS42
      Related
      ENSP00000438930.1, ENST00000545523.5
      Conserved Domains (3) summary
      smart00349
      Location:1 → 61
      KRAB; krueppel associated box
      COG5048
      Location:268 → 499
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259 → 279
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_047438808.1 → XP_047294764.1  zinc finger protein 324B isoform X1

      UniProtKB/Swiss-Prot
      B2RTZ6, Q6AW86, Q6ZMX8, Q6ZS42

    6. XM_047438809.1 → XP_047294765.1  zinc finger protein 324B isoform X1

      UniProtKB/Swiss-Prot
      B2RTZ6, Q6AW86, Q6ZMX8, Q6ZS42

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      61514353..61553798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320976.1 → XP_054176951.1  zinc finger protein 324B isoform X2

    2. XM_054320975.1 → XP_054176950.1  zinc finger protein 324B isoform X1

      UniProtKB/Swiss-Prot
      B2RTZ6, Q6AW86, Q6ZMX8, Q6ZS42

    3. XM_054320974.1 → XP_054176949.1  zinc finger protein 324B isoform X1

      UniProtKB/Swiss-Prot
      B2RTZ6, Q6AW86, Q6ZMX8, Q6ZS42

    4. XM_054320979.1 → XP_054176954.1  zinc finger protein 324B isoform X1

      UniProtKB/Swiss-Prot
      B2RTZ6, Q6AW86, Q6ZMX8, Q6ZS42

    5. XM_054320977.1 → XP_054176952.1  zinc finger protein 324B isoform X1

      UniProtKB/Swiss-Prot
      B2RTZ6, Q6AW86, Q6ZMX8, Q6ZS42

    6. XM_054320978.1 → XP_054176953.1  zinc finger protein 324B isoform X1

      UniProtKB/Swiss-Prot
      B2RTZ6, Q6AW86, Q6ZMX8, Q6ZS42
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AW86.1 GenPept UniProtKB/Swiss-Prot:Q6AW86

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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