Zhx2 zinc fingers and homeoboxes 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zhx2provided by MGI
Official Full Name: zinc fingers and homeoboxes 2provided by MGI
Primary source: MGI:MGI:2683087
See related: Ensembl:ENSMUSG00000071757 AllianceGenome:MGI:2683087
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Raf; Afr1; Afr-1; mKIAA0854
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; protein heterodimerization activity; and protein homodimerization activity. Involved in retinal bipolar neuron differentiation. Acts upstream of or within negative regulation of macromolecule biosynthetic process; negative regulation of neuron differentiation; and somatic stem cell population maintenance. Is active in nucleus. Is expressed in brain; liver; and renal vasculature. Orthologous to human ZHX2 (zinc fingers and homeoboxes 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 5.9), spleen adult (RPKM 5.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D1; 15 24.01 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (57558063..57703228)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (57694667..57839832)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Elongation of very long chain fatty acids-3 (Elovl3) is activated by ZHX2 and is a regulator of cell cycle progression.
Title: Elongation of very long chain fatty acids-3 (Elovl3) is activated by ZHX2 and is a regulator of cell cycle progression.
Transcription factor Zhx2 is a checkpoint that programs macrophage polarization and antitumor response.
Title: Transcription factor Zhx2 is a checkpoint that programs macrophage polarization and antitumor response.
Zinc fingers and homeoboxes 2 is required for diethylnitrosamine-induced liver tumor formation in C57BL/6 mice.
Title: Zinc fingers and homeoboxes 2 is required for diethylnitrosamine-induced liver tumor formation in C57BL/6 mice.
Novel regulation of the transcription factor ZHX2 by N-terminal methylation.
Title: Novel regulation of the transcription factor ZHX2 by N-terminal methylation.
Zhx2 Is a Candidate Gene Underlying Oxymorphone Metabolite Brain Concentration Associated with State-Dependent Oxycodone Reward.
Title: Zhx2 Is a Candidate Gene Underlying Oxymorphone Metabolite Brain Concentration Associated with State-Dependent Oxycodone Reward.
The transcription factor zinc fingers and homeoboxes 2 alleviates NASH by transcriptional activation of phosphatase and tensin homolog.
Title: The transcription factor zinc fingers and homeoboxes 2 alleviates NASH by transcriptional activation of phosphatase and tensin homolog.
Transcription factor Zhx2 restricts NK cell maturation and suppresses their antitumor immunity.
Title: Transcription factor Zhx2 restricts NK cell maturation and suppresses their antitumor immunity.
Zhx2 Accelerates Sepsis by Promoting Macrophage Glycolysis via Pfkfb3.
Title: Zhx2 Accelerates Sepsis by Promoting Macrophage Glycolysis via Pfkfb3.
On the high-fat chow, BALB/cJ mice with a mutation encoding the transcription factor Zinc fingers and homeoboxes 2 (Zhx2) have increased weight gain, increased liver:body weight ratio, elevated hepatic lipid accumulation and markers of liver damage when compared to BALB/c mice. These traits in BALB/cJ mice are only partially reversed by a hepatocyte-specific Zhx2 transgene.
Title: Liver size and lipid content differences between BALB/c and BALB/cJ mice on a high-fat diet are due, in part, to Zhx2.
Zhx2 is expressed in developing retina. Zhx2 is essential for subsets of bipolar cell proper differentiation. Overexpression of Zhx2 showed perturbation of bipolar differentiation.
Title: The role of Zhx2 transcription factor in bipolar cell differentiation during mouse retinal development.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Spontaneous (1) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within mRNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinal bipolar neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somatic stem cell population maintenance	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: zinc fingers and homeoboxes protein 2

Names: AFP regulator 1; alpha fetoprotein regulation 1, adult; alpha-fetoprotein regulator 1; regulator of AFP; zinc finger and homeodomain protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199449.2 → NP_955520.1 zinc fingers and homeoboxes protein 2

See identical proteins and their annotated locations for NP_955520.1

Status: VALIDATED

Source sequence(s)

AC102895, BC059178, BQ174722

Consensus CDS

CCDS27483.1

UniProtKB/Swiss-Prot

Q8C0C0

UniProtKB/TrEMBL

Q3TZR8

Related

ENSMUSP00000094164.5, ENSMUST00000096430.11

Conserved Domains (3) summary

smart00389
Location:537 → 582

HOX; Homeodomain

cd00086
Location:444 → 496

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

pfam18387
Location:106 → 158

zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

57558063..57703228

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011245688.4 → XP_011243990.1 zinc fingers and homeoboxes protein 2 isoform X1

See identical proteins and their annotated locations for XP_011243990.1

UniProtKB/Swiss-Prot

Q8C0C0

UniProtKB/TrEMBL

Q3TZR8

Conserved Domains (3) summary

smart00389
Location:537 → 582

HOX; Homeodomain

cd00086
Location:444 → 496

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

pfam18387
Location:106 → 158

zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain
XM_011245689.3 → XP_011243991.1 zinc fingers and homeoboxes protein 2 isoform X1

See identical proteins and their annotated locations for XP_011243991.1

UniProtKB/Swiss-Prot

Q8C0C0

UniProtKB/TrEMBL

Q3TZR8

Conserved Domains (3) summary

smart00389
Location:537 → 582

HOX; Homeodomain

cd00086
Location:444 → 496

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

pfam18387
Location:106 → 158

zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain