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    Atg2 Autophagy-related 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38344, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Atg2provided by FlyBase
    Official Full Name
    Autophagy-related 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0044452
    Locus tag
    Dmel_CG1241
    See related
    AllianceGenome:FB:FBgn0044452
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    atg2; ATG2; CG1241; Dmel\CG1241; EP3697
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity and protein-membrane adaptor activity. Involved in cellular response to starvation; larval midgut cell programmed cell death; and macroautophagy. Predicted to be active in phagophore and phagophore assembly site. Is expressed in adult head and salivary gland. Orthologous to human ATG2A (autophagy related 2A) and ATG2B (autophagy related 2B). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

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    See Atg2 in Genome Data Viewer
    Location:
    62F3-62F4; 3-4 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2774338..2780677)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2774338..2780677)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Adenosylhomocysteinase like 1 Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein S35 Neighboring gene Polypeptide N-Acetylgalactosaminyltransferase 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lipid profiles of autophagic structures isolated from wild type and Atg2 mutant Drosophila. Laczkó-Dobos H, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2021 Mar. PMID 33333179, Free PMC Article
    2. Atg2 Regulates Cellular and Humoral Immunity in Drosophila. Qin B, et al. Insects, 2023 Aug 14. PMID 37623416, Free PMC Article
    3. Autophagic cell death: Loch Ness monster or endangered species? Shen HM, et al. Autophagy, 2011 May. PMID 21150268
    4. Functional analysis of host factors that mediate the intracellular lifestyle of Cryptococcus neoformans. Qin QM, et al. PLoS Pathog, 2011 Jun. PMID 21698225, Free PMC Article
    5. Muscle-specific overexpression of Atg2 gene and endurance exercise delay age-related deteriorations of skeletal muscle and heart function via activating the AMPK/Sirt1/PGC-1α pathway in male Drosophila. Wang JF, et al. FASEB J, 2023 Nov. PMID 37773768

    See all (116) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Muscle-specific overexpression of Atg2 gene and endurance exercise delay age-related deteriorations of skeletal muscle and heart function via activating the AMPK/Sirt1/PGC-1alpha pathway in male Drosophila.
      Title: Muscle-specific overexpression of Atg2 gene and endurance exercise delay age-related deteriorations of skeletal muscle and heart function via activating the AMPK/Sirt1/PGC-1α pathway in male Drosophila.
    2. Lipid profiles of autophagic structures isolated from wild type and Atg2 mutant Drosophila.
      Title: Lipid profiles of autophagic structures isolated from wild type and Atg2 mutant Drosophila.
    3. These findings provide the first direct evidence of the importance of Atg2-Atg18/Atg9 autophagy complex in the maintenance of mitochondrial integrity and, regulation of heart and muscle functions in Drosophila.
      Title: Atg2, Atg9 and Atg18 in mitochondrial integrity, cardiac function and healthspan in Drosophila.
    4. Stusy results reveal Atg2 regulation by STAT signalling as a mechanism by which cytokines can control lipid droplet homeostasis and consequently resistance to mycobacterial infection in Drosophila.
      Title: Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection.
    5. double knockdown of tlk and atg2 by RNAi did not have a synergistic effect. These results suggested that ATG2 may function downstream of TLK. In addition to a role in development, tlk and atg2 RNAi could rescue calcium overload-induced cell death
      Title: Tousled-like kinase mediated a new type of cell death pathway in Drosophila.
    6. Atg2 and ArfGAP1 may have roles in modifying the eye pigmentation phenotype of AP-3 mutants in Drosophila melanogaster
      Title: Identification of Atg2 and ArfGAP1 as Candidate Genetic Modifiers of the Eye Pigmentation Phenotype of Adaptor Protein-3 (AP-3) Mutants in Drosophila melanogaster.
    7. The transmembrane protein Atg9 accumulates on refractory to Sigma P (Ref(2)P) aggregates in Atg7, Atg8a and Atg2 mutants.
      Title: Different effects of Atg2 and Atg18 mutations on Atg8a and Atg9 trafficking during starvation in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval midgut cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval midgut histolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pexophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reticulophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in wound healing HMP PubMed 
    Component Evidence Code Pubs
    is_active_in phagophore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagophore assembly site ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Autophagy-related 2
    Names
    Atg2-PA
    Atg2-PB
    Autophagy-specific gene 2
    CG1241-PA
    CG1241-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      2774338..2780677
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274412.1 → NP_001261341.1  Autophagy-related 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261341.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2XXT6, Q9VZX7
      Conserved Domains (2) summary
      pfam09333
      Location:1814 → 1902
      ATG_C; Autophagy-related protein C terminal domain
      pfam12624
      Location:17 → 117
      Chorein_N; N-terminal region of Chorein or VPS13

    2. NM_139491.2 → NP_647748.1  Autophagy-related 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647748.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2XXT6, Q9VZX7
      Related
      FBpp0072840
      Conserved Domains (2) summary
      pfam09333
      Location:1814 → 1902
      ATG_C; Autophagy-related protein C terminal domain
      pfam12624
      Location:17 → 117
      Chorein_N; N-terminal region of Chorein or VPS13
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2XXT6 Q2XXT6
    Q95TX2 Q95TX2
    Q9VZX7 Q9VZX7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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