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    Mrs2 MRS2 magnesium transporter [ Mus musculus (house mouse) ]

    Gene ID: 380836, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mrs2provided by MGI
    Official Full Name
    MRS2 magnesium transporterprovided by MGI
    Primary source
    MGI:MGI:2685748
    See related
    Ensembl:ENSMUSG00000021339 AllianceGenome:MGI:2685748
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HPT; RPT; Gm902; Mrs2l
    Summary
    Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in lactate metabolic process and mitochondrial magnesium ion transmembrane transport. Located in mitochondrion. Orthologous to human MRS2 (magnesium transporter MRS2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 14.1), colon adult (RPKM 13.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mrs2 in Genome Data Viewer
    Location:
    13 A3.1; 13 10.83 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (25171466..25204345, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (24987483..25020363, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene glycosylphosphatidylinositol specific phospholipase D1 Neighboring gene predicted gene, 34019 Neighboring gene microRNA 12184 Neighboring gene predicted gene, 52042 Neighboring gene STARR-positive B cell enhancer mm9_chr13:25142251-25142552 Neighboring gene STARR-seq mESC enhancer starr_33992 Neighboring gene doublecortin domain containing 2a Neighboring gene STARR-seq mESC enhancer starr_33993 Neighboring gene neurensin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Limiting Mrs2-dependent mitochondrial Mg(2+) uptake induces metabolic programming in prolonged dietary stress. Madaris TR, et al. Cell Rep, 2023 Mar 28. PMID 36857182, Free PMC Article
    2. Mice Lacking Mrs2 Magnesium Transporter are Hypophagic and Thin When Maintained on a High-Fat Diet. Powell DR, et al. Endocrinology, 2024 Jul 1. PMID 38878275
    3. Mrs2-mediated mitochondrial magnesium uptake is essential for the regulation of MCU-mediated mitochondrial Ca(2+) uptake and viability. Ponnusamy T, et al. Mitochondrion, 2024 May. PMID 38599304
    4. ERMA (TMEM94) is a P-type ATPase transporter for Mg(2+) uptake in the endoplasmic reticulum. Vishnu N, et al. Mol Cell, 2024 Apr 4. PMID 38513662,
    5. Lactate Elicits ER-Mitochondrial Mg(2+) Dynamics to Integrate Cellular Metabolism. Daw CC, et al. Cell, 2020 Oct 15. PMID 33035451, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mice Lacking Mrs2 Magnesium Transporter are Hypophagic and Thin When Maintained on a High-Fat Diet.
      Title: Mice Lacking Mrs2 Magnesium Transporter are Hypophagic and Thin When Maintained on a High-Fat Diet.
    2. Limiting Mrs2-dependent mitochondrial Mg[2+] uptake induces metabolic programming in prolonged dietary stress.
      Title: Limiting Mrs2-dependent mitochondrial Mg(2+) uptake induces metabolic programming in prolonged dietary stress.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables magnesium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lactate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lactate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial magnesium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial magnesium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial magnesium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    magnesium transporter MRS2 homolog, mitochondrial
    Names
    MRS2 magnesium homeostasis factor homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013389.2 → NP_001013407.2  magnesium transporter MRS2 homolog, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001013407.2

      Status: VALIDATED

      Source sequence(s)
      AL645533, AW456688, BB015377, BU058305, CA752560
      Consensus CDS
      CCDS26385.2
      UniProtKB/Swiss-Prot
      Q5NCE8
      Related
      ENSMUSP00000021772.4, ENSMUST00000021772.4
      Conserved Domains (1) summary
      cd12823
      Location:79 → 390
      Mrs2_Mfm1p-like; Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      25171466..25204345 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516707.5 → XP_006516770.2  magnesium transporter MRS2 homolog, mitochondrial isoform X1

      Conserved Domains (1) summary
      cd12823
      Location:79 → 351
      Mrs2_Mfm1p-like; Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5NCE8.2 GenPept UniProtKB/Swiss-Prot:Q5NCE8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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