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    Begain brain-enriched guanylate kinase-associated [ Mus musculus (house mouse) ]

    Gene ID: 380785, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Begainprovided by MGI
    Official Full Name
    brain-enriched guanylate kinase-associatedprovided by MGI
    Primary source
    MGI:MGI:3044626
    See related
    Ensembl:ENSMUSG00000040867 AllianceGenome:MGI:3044626
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm897
    Summary
    Involved in regulation of postsynaptic neurotransmitter receptor activity. Acts upstream of or within evoked excitatory postsynaptic potential. Located in glutamatergic synapse and presynapse. Is expressed in central nervous system; eye; and lip. Orthologous to human BEGAIN (brain enriched guanylate kinase associated). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 24.5), frontal lobe adult (RPKM 23.8) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Begain in Genome Data Viewer
    Location:
    12 F1; 12 59.98 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (108998107..109034168, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (109032181..109068242, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5353 Neighboring gene STARR-seq mESC enhancer starr_33252 Neighboring gene predicted gene, 22079 Neighboring gene STARR-seq mESC enhancer starr_33253 Neighboring gene tryptophanyl-tRNA synthetase1 Neighboring gene WD repeat domain 25 Neighboring gene STARR-seq mESC enhancer starr_33254 Neighboring gene STARR-seq mESC enhancer starr_33255 Neighboring gene peptidyl prolyl isomerase H pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:110295982-110296239 Neighboring gene STARR-positive B cell enhancer mm9_chr12:110312387-110312688 Neighboring gene STARR-positive B cell enhancer mm9_chr12:110313106-110313407 Neighboring gene predicted gene, 52002 Neighboring gene macrophage migration inhibitory factor, pseudogene 7 Neighboring gene STARR-seq mESC enhancer starr_33259 Neighboring gene STARR-seq mESC enhancer starr_33260 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:110676232-110676385 Neighboring gene delta like non-canonical Notch ligand 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Begain gene marks the centromeric boundary of the imprinted region on mouse chromosome 12. Tierling S, et al. Mamm Genome, 2009 Sep-Oct. PMID 19641963
    2. Involvement of Brain-Enriched Guanylate Kinase-Associated Protein (BEGAIN) in Chronic Pain after Peripheral Nerve Injury. Katano T, et al. eNeuro, 2016 Sep-Oct. PMID 27785460, Free PMC Article
    3. Klf14 is an imprinted transcription factor that regulates placental growth. Koppes E, et al. Placenta, 2019 Dec. PMID 31675530, Free PMC Article
    4. ZFP57 dictates allelic expression switch of target imprinted genes. Jiang W, et al. Proc Natl Acad Sci U S A, 2021 Feb 2. PMID 33500348, Free PMC Article
    5. Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome. Li J, et al. Sci Signal, 2016 Aug 9. PMID 27507650

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in evoked excitatory postsynaptic potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within evoked excitatory postsynaptic potential IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    brain-enriched guanylate kinase-associated protein
    Names
    brain-enriched guanylate kinase-associated; brain-enriched guanylate kinase-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163175.1 → NP_001156647.1  brain-enriched guanylate kinase-associated protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AK158915, BC080282
      Consensus CDS
      CCDS56862.1
      UniProtKB/TrEMBL
      A0A087WQY4, F8WIG2
      Related
      ENSMUSP00000140393.3, ENSMUST00000190647.3
      Conserved Domains (2) summary
      COG1196
      Location:21 → 143
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:510 → 618
      Pilt; Protein incorporated later into Tight Junctions

    2. NM_001374200.1 → NP_001361129.1  brain-enriched guanylate kinase-associated protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC140111
      Conserved Domains (2) summary
      TIGR02168
      Location:56 → 170
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15453
      Location:540 → 648
      Pilt; Protein incorporated later into Tight Junctions

    3. NM_001374201.1 → NP_001361130.1  brain-enriched guanylate kinase-associated protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC140111
      Conserved Domains (2) summary
      COG1196
      Location:19 → 141
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:508 → 616
      Pilt; Protein incorporated later into Tight Junctions

    4. NM_001374202.1 → NP_001361131.1  brain-enriched guanylate kinase-associated protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC140111
      Consensus CDS
      CCDS88401.1
      UniProtKB/TrEMBL
      A0A5F8MPR2
      Related
      ENSMUSP00000159072.2, ENSMUST00000239108.2
      Conserved Domains (2) summary
      COG1196
      Location:5 → 137
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:504 → 612
      Pilt; Protein incorporated later into Tight Junctions

    5. NM_001374203.1 → NP_001361132.1  brain-enriched guanylate kinase-associated protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC140111
      Consensus CDS
      CCDS88400.1
      UniProtKB/Swiss-Prot
      Q68EF6
      Conserved Domains (2) summary
      COG1196
      Location:2 → 124
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:491 → 599
      Pilt; Protein incorporated later into Tight Junctions

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      108998107..109034168 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244128.3 → XP_011242430.1  brain-enriched guanylate kinase-associated protein isoform X3

      See identical proteins and their annotated locations for XP_011242430.1

      Conserved Domains (2) summary
      TIGR02168
      Location:37 → 151
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15453
      Location:521 → 629
      Pilt; Protein incorporated later into Tight Junctions

    2. XM_006516044.3 → XP_006516107.1  brain-enriched guanylate kinase-associated protein isoform X4

      See identical proteins and their annotated locations for XP_006516107.1

      UniProtKB/Swiss-Prot
      Q68EF6
      Related
      ENSMUSP00000158999.2, ENSMUST00000238841.2
      Conserved Domains (2) summary
      COG1196
      Location:2 → 124
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:491 → 599
      Pilt; Protein incorporated later into Tight Junctions

    3. XM_006516041.5 → XP_006516104.1  brain-enriched guanylate kinase-associated protein isoform X2

      Conserved Domains (2) summary
      TIGR02168
      Location:50 → 164
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15453
      Location:534 → 642
      Pilt; Protein incorporated later into Tight Junctions

    4. XM_006516040.5 → XP_006516103.1  brain-enriched guanylate kinase-associated protein isoform X1

      Conserved Domains (2) summary
      TIGR02168
      Location:54 → 168
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15453
      Location:538 → 646
      Pilt; Protein incorporated later into Tight Junctions
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68EF6.2 GenPept UniProtKB/Swiss-Prot:Q68EF6

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