slc22a5.L solute carrier family 22 member 5 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: slc22a5.L
Official Full Name: solute carrier family 22 member 5 L homeolog
Primary source: Xenbase:XB-GENE-484420
Locus tag: XELAEV_18017159mg
See related: EnsemblRapid:ENSXLAG00005027227 AllianceGenome:Xenbase:XB-GENE-484420
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: octn2; slc22a5
Summary: Predicted to enable ATP binding activity and quaternary ammonium group transmembrane transporter activity. Predicted to act upstream of or within carnitine transport; sodium ion transport; and transmembrane transport. Predicted to be located in basal plasma membrane. Human ortholog(s) of this gene implicated in Crohn's disease; cardiomyopathy; inherited metabolic disorder; and systemic primary carnitine deficiency disease. Orthologous to human SLC22A5 (solute carrier family 22 member 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 3L

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3L	NC_054375.1 (43877822..43907637)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3L	NC_030728.1 (29501254..29531043)

Chromosome 3L - NC_054375.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables quaternary ammonium group transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carnitine transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within quaternary ammonium group transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sodium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basal plasma membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: solute carrier family 22 member 5 L homeolog

Names: solute carrier family 22 (organic cation transporter), member 5; solute carrier family 22 (organic cation/carnitine transporter), member 5 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087429.1 → NP_001080898.1 solute carrier family 22 member 5 L homeolog

See identical proteins and their annotated locations for NP_001080898.1

Status: PROVISIONAL

Source sequence(s)

BC056014

UniProtKB/TrEMBL

A0A974DCU2, Q7T0W2

Related

ENSXLAP00005080928.1, ENSXLAT00005082537.1

Conserved Domains (2) summary

cd06174
Location:116 → 504

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00898
Location:12 → 514

2A0119; cation transport protein