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    BLLF1 glycoprotein 350 [ Human gammaherpesvirus 4 (Epstein-Barr virus) ]

    Gene ID: 3783713, updated on 20-Nov-2023

    Summary

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    Gene symbol
    BLLF1
    Gene description
    glycoprotein 350
    Locus tag
    HHV4_BLLF1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Human gammaherpesvirus 4 (strain: B95-8, strain: Raji, type: 1, common: Epstein-Barr virus, acronym: EBV, acronym: HHV-4, nat-host: Homo sapiens)
    Lineage
    Viruses; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus
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    Genomic context

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    Sequence:
    NC_007605.1 (77132..79904, complement)

    NC_007605.1Genomic Context describing neighboring genes Neighboring gene nuclear antigen EBNA-3B;nuclear antigen EBNA-3C Neighboring gene nuclear antigen EBNA-3A Neighboring gene protein-coding Neighboring gene nuclear antigen EBNA-1 Neighboring gene deoxyuridine triphosphatase Neighboring gene envelope glycoprotein N Neighboring gene virion protein G52 Neighboring gene protein BLLF2 Neighboring gene envelope glycoprotein 42 Neighboring gene protein Zta Neighboring gene protein Rta

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_007605.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of Epstein-Barr virus gp350/220 gene variants in virus isolates from gastric carcinoma and nasopharyngeal carcinoma. Luo B, et al. Arch Virol, 2012 Feb. PMID 22038027
    2. Epstein-Barr viruses that express a CD21 antibody provide evidence that gp350's functions extend beyond B-cell surface binding. Busse C, et al. J Virol, 2010 Jan. PMID 19889766, Free PMC Article
    3. Molecular basis of the interaction between complement receptor type 2 (CR2/CD21) and Epstein-Barr virus glycoprotein gp350. Young KA, et al. J Virol, 2008 Nov. PMID 18786993, Free PMC Article
    4. Structure of the Epstein-Barr virus major envelope glycoprotein. Szakonyi G, et al. Nat Struct Mol Biol, 2006 Nov. PMID 17072314
    5. Updated Epstein-Barr virus (EBV) DNA sequence and analysis of a promoter for the BART (CST, BARF0) RNAs of EBV. de Jesus O, et al. J Gen Virol, 2003 Jun. PMID 12771413

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The similar distribution of gp350/220 variants in nasopharyngeal carcinoma, EBV-associated gastric carcinoma and healthy donors suggest that gp350/220 variations are geographically restricted rather than tumor-specific polymorphisms.
      Title: Characterization of Epstein-Barr virus gp350/220 gene variants in virus isolates from gastric carcinoma and nasopharyngeal carcinoma.
    2. gp350 mainly exerts its functions after the internalization step, presumably during release of the viral capsid from the endosomal compartment, and that CD21-dependent but also CD21-independent molecular mechanisms are involved in this process.
      Title: Epstein-Barr viruses that express a CD21 antibody provide evidence that gp350's functions extend beyond B-cell surface binding.
    3. These site-directed mutations identified a novel negatively charged complement receptor type 2-binding surface described by residues Glu-21, Asp-22, Glu-155, Asp-208, Glu-210, and Asp-296.
      Title: Molecular basis of the interaction between complement receptor type 2 (CR2/CD21) and Epstein-Barr virus glycoprotein gp350.
    4. X-ray structure of the highly glycosylated gp350; defined the CR2 binding site on gp350, deglycosylated gp350 bound CR2 similarly to the glycosylated form, suggesting that glycosylation is not important for receptor binding
      Title: Structure of the Epstein-Barr virus major envelope glycoprotein.
    Submit: New GeneRIF Correction

    General gene information

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    regulatory

    • Loc: c77137-77132 regulatory_class = polyA_signal_sequence
    • Loc: c77763-77758 regulatory_class = TATA_box
    • Loc: c79904-79899 regulatory_class = TATA_box

    General protein information

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    Preferred Names
    glycoprotein 350

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_007605.1 Reference assembly

      Range
      77132..79904 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_401667.1 glycoprotein 350 [Human gammaherpesvirus 4]

      See identical proteins and their annotated locations for YP_401667.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P03200, P03201, Q66536, Q66537, Q777F0
      UniProtKB/TrEMBL
      A0A0B6VN60, A0A0X9A9C5, A0A2S1N356
      Conserved Domains (1) summary
      pfam05109
      Location:1 → 907
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    Nucleotide Protein
    Heading Accession and Version

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