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    Sxl Sex lethal [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3772180, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Sxlprovided by FlyBase
    Official Full Name
    Sex lethalprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264270
    Locus tag
    Dmel_CG43770
    See related
    AllianceGenome:FB:FBgn0264270
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14425; CG18350; CG33070; CG43770; Dm-Sxl; Dmel\CG43770; DmSxl; dSXL; Fl; fs(1)K1274; fs(1)M106; l(1)6Fa; melSxl; Mex156; ORF2; Su(da); Sx1; sxl; SxL; SXL; Sxl-1 Sxl-2; Sxl-Pe; SxlPe; SxlPm
    Old locus tag
    Dmel_CG14425; Dmel_CG18350
    Summary
    Enables nucleic acid binding activity. Involved in several processes, including female germ-line sex determination; oogenesis; and regulation of RNA splicing. Part of protein-containing complex. Is active in cytoplasm and nucleus. Is expressed in several structures, including adult head; adult midgut epithelial cell; antennal lobe local neurons; germline cell; and somatic precursor cell. [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    all
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    Genomic context

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    See Sxl in Genome Data Viewer
    Location:
    6F3-6F5; 1-19 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7074550..7098053, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6968583..6992089, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene nullo Neighboring gene uncharacterized protein Neighboring gene mir-4956 stem loop Neighboring gene long non-coding RNA:CR46494 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Normal female germ cell differentiation requires the female X chromosome to autosome ratio and expression of sex-lethal in Drosophila melanogaster. Schüpbach T. Genetics, 1985 Mar. PMID 3920120, Free PMC Article
    2. A characteristic arrangement of aromatic amino acid residues in the solution structure of the amino-terminal RNA-binding domain of Drosophila sex-lethal. Inoue M, et al. J Mol Biol, 1997 Sep 12. PMID 9299339
    3. Control of Drosophila Sex-lethal pre-mRNA splicing by its own female-specific product. Sakamoto H, et al. Nucleic Acids Res, 1992 Nov 11. PMID 1454517, Free PMC Article
    4. Molecular titration and ultrasensitivity in regulatory networks. Buchler NE, et al. J Mol Biol, 2008 Dec 31. PMID 18938177
    5. Evidence that processed small dsRNAs may mediate sequence-specific mRNA degradation during RNAi in Drosophila embryos. Yang D, et al. Curr Biol, 2000 Oct 5. PMID 11050387

    See all (676) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sex-lethal regulates back-splicing and generation of the sex-differentially expressed circular RNAs.
      Title: Sex-lethal regulates back-splicing and generation of the sex-differentially expressed circular RNAs.
    2. Noncanonical function of the Sex lethal gene controls the protogyny phenotype in Drosophila melanogaster.
      Title: Noncanonical function of the Sex lethal gene controls the protogyny phenotype in Drosophila melanogaster.
    3. Antagonism between germ cell-less and Torso receptor regulates transcriptional quiescence underlying germline/soma distinction.
      Title: Antagonism between germ cell-less and Torso receptor regulates transcriptional quiescence underlying germline/soma distinction.
    4. Molecular population genetics of Sex-lethal (Sxl) in the Drosophila melanogaster species group: a locus that genetically interacts with Wolbachia pipientis in Drosophila melanogaster.
      Title: Molecular population genetics of Sex-lethal (Sxl) in the Drosophila melanogaster species group: a locus that genetically interacts with Wolbachia pipientis in Drosophila melanogaster.
    5. Study provides evidence that Sxl promotes female identity in germ cells by repressing genes, like Tdrd5l, that promote male identity.
      Title: Tudor-domain containing protein 5-like promotes male sexual identity in the Drosophila germline and is repressed in females by Sex lethal.
    6. demonstration that Ssx safeguards male animals against Sxl protein production to reinforce a stable, male-specific gene expression pattern
      Title: Drosophila Sister-of-Sex-lethal reinforces a male-specific gene expression pattern by controlling Sex-lethal alternative splicing.
    7. we observed that Dx together with Hrp48 can regulate Notch signaling in an Sxl-independent manner. In addition, Dx and Hrp48 displayed a synergistic effect on caspase-mediated cell death. Our results suggest that Dx and Hrp48 together negatively regulate Notch signaling in Drosophila melanogaster.
      Title: Regulation of Notch Signaling by the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex in Drosophila melanogaster.
    8. this study we have used the CRISPR/Cas9 system to introduce site-specific mutations in the D. suzukii white (w) and Sex lethal (Sxl) genes.
      Title: CRISPR/Cas9-mediated mutagenesis of the white and Sex lethal loci in the invasive pest, Drosophila suzukii.
    9. Sxl is necessary for the cell-autonomous maintenance of germ cell female identity.
      Title: Maintenance of Drosophila germline stem cell sexual identity in oogenesis and tumorigenesis.
    10. 2.8 A crystal structure, NMR and small-angle X-ray and neutron scattering data of the ternary Sxl-Unr-msl2 ribonucleoprotein complex featuring unprecedented intertwined interactions of two Sxl RNA recognition motifs, a Unr cold-shock domain and RNA
      Title: Structural basis for the assembly of the Sxl-Unr translation regulatory complex.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA 3'-UTR binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables mRNA 5'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA 5'-UTR binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA regulatory element binding translation repressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA regulatory element binding translation repressor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(U) RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(U) RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables poly-pyrimidine tract binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pre-mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in alternative mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epithelium regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female germ-line sex determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female sex determination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in female sex determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germarium-derived cystoblast division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of RNA export from nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of translational initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of RNA splicing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of smoothened signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sex determination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sex determination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in sex determination, primary response to X:A ratio TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in sex differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in sex-chromosome dosage compensation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in somatic sex determination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sex lethal
    Names
    CG43770-PA
    CG43770-PAA
    CG43770-PAB
    CG43770-PAC
    CG43770-PB
    CG43770-PC
    CG43770-PD
    CG43770-PE
    CG43770-PF
    CG43770-PG
    CG43770-PH
    CG43770-PJ
    CG43770-PK
    CG43770-PL
    CG43770-PM
    CG43770-PN
    CG43770-PO
    CG43770-PP
    CG43770-PQ
    CG43770-PR
    CG43770-PT
    CG43770-PW
    CG43770-PX
    CG43770-PY
    CG43770-PZ
    Sex-kethal
    Sxl-PA
    Sxl-PAA
    Sxl-PAB
    Sxl-PAC
    Sxl-PB
    Sxl-PC
    Sxl-PD
    Sxl-PE
    Sxl-PF
    Sxl-PG
    Sxl-PH
    Sxl-PJ
    Sxl-PK
    Sxl-PL
    Sxl-PM
    Sxl-PN
    Sxl-PO
    Sxl-PP
    Sxl-PQ
    Sxl-PR
    Sxl-PT
    Sxl-PW
    Sxl-PX
    Sxl-PY
    Sxl-PZ
    female lethal
    sex-lethal
    sexlethal

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      7074550..7098053 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001031891.3 → NP_001027062.1  Sex lethal, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027062.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH95
      Conserved Domains (2) summary
      cd12376
      Location:201 → 279
      RRM2_Hu_like; RNA recognition motif 2 in the Hu proteins family, Drosophila sex-lethal (SXL), and similar proteins
      cd12649
      Location:115 → 195
      RRM1_SXL; RNA recognition motif 1 in Drosophila sex-lethal (SXL) and similar proteins

    2. NM_001272374.1 → NP_001259303.1  Sex lethal, isoform X [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259303.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGK6
      Conserved Domains (2) summary
      cd12376
      Location:203 → 281
      RRM2_Hu_like; RNA recognition motif 2 in the Hu proteins family, Drosophila sex-lethal (SXL), and similar proteins
      cd12649
      Location:117 → 197
      RRM1_SXL; RNA recognition motif 1 in Drosophila sex-lethal (SXL) and similar proteins

    3. NM_167114.2 → NP_727164.2  Sex lethal, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727164.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH95
      Conserved Domains (2) summary
      cd12376
      Location:203 → 281
      RRM2_Hu_like; RNA recognition motif 2 in the Hu proteins family, Drosophila sex-lethal (SXL), and similar proteins
      cd12649
      Location:117 → 197
      RRM1_SXL; RNA recognition motif 1 in Drosophila sex-lethal (SXL) and similar proteins

    4. NM_001169215.2 → NP_001162686.1  Sex lethal, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162686.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A140B9G0
      Conserved Domains (3) summary
      cd12376
      Location:211 → 289
      RRM2_Hu_like; RNA recognition motif 2 in the Hu proteins family, Drosophila sex-lethal (SXL), and similar proteins
      cd12649
      Location:125 → 205
      RRM1_SXL; RNA recognition motif 1 in Drosophila sex-lethal (SXL) and similar proteins
      TIGR01659
      Location:16 → 332
      sex-lethal; sex-lethal family splicing factor

    5. NM_001272375.2 → NP_001259304.1  Sex lethal, isoform Y [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259304.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHB3
      Conserved Domains (3) summary
      cd12376
      Location:211 → 289
      RRM2_Hu_like; RNA recognition motif 2 in the Hu proteins family, Drosophila sex-lethal (SXL), and similar proteins
      cd12649
      Location:125 → 205
      RRM1_SXL; RNA recognition motif 1 in Drosophila sex-lethal (SXL) and similar proteins
      TIGR01659
      Location:16 → 332
      sex-lethal; sex-lethal family splicing factor

    6. NM_001031893.2 → NP_001027064.1  Sex lethal, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027064.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PJB1

    7. NM_001169217.2 → NP_001162688.1  Sex lethal, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162688.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH95
      Conserved Domains (2) summary
      cd12376
      Location:201 → 279
      RRM2_Hu_like; RNA recognition motif 2 in the Hu proteins family, Drosophila sex-lethal (SXL), and similar proteins
      cd12649
      Location:115 → 195
      RRM1_SXL; RNA recognition motif 1 in Drosophila sex-lethal (SXL) and similar proteins

    8. NM_167111.3 → NP_727161.3  Sex lethal, isoform W [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727161.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH95, F0JAP9
      Conserved Domains (3) summary
      cd12376
      Location:203 → 281
      RRM2_Hu_like; RNA recognition motif 2 in the Hu proteins family, Drosophila sex-lethal (SXL), and similar proteins
      cd12649
      Location:117 → 197
      RRM1_SXL; RNA recognition motif 1 in Drosophila sex-lethal (SXL) and similar proteins
      TIGR01659
      Location:16 → 324
      sex-lethal; sex-lethal family splicing factor

    9. NM_167112.2 → NP_727162.2  Sex lethal, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727162.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V434, A4V435, A4V436, A4V437, C9QP40, D0IQK2, D3PFI6, E1JJI8, E1JJI9, E1JJJ0, E1JJJ2, E1JJJ3, P19339, P19340, Q0KHV2, Q26466, Q2MGN7, Q2MGN8, Q2MGN9, Q2MGP1, Q7KVU6, Q7YZ92, Q8IRQ1, Q99141, Q9TYF5, Q9W3S6
      UniProtKB/TrEMBL
      E8NH95
      Conserved Domains (3) summary
      cd12376
      Location:211 → 289
      RRM2_Hu_like; RNA recognition motif 2 in the Hu proteins family, Drosophila sex-lethal (SXL), and similar proteins
      cd12649
      Location:125 → 205
      RRM1_SXL; RNA recognition motif 1 in Drosophila sex-lethal (SXL) and similar proteins
      TIGR01659
      Location:16 → 354
      sex-lethal; sex-lethal family splicing factor

    10. NM_167117.2 → NP_727167.2  Sex lethal, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727167.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PJB1

    11. NM_001272376.1 → NP_001259305.1  Sex lethal, isoform Z [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259305.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGW6

    12. NM_167116.2 → NP_727166.2  Sex lethal, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727166.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH95
      Conserved Domains (3) summary
      cd12376
      Location:203 → 281
      RRM2_Hu_like; RNA recognition motif 2 in the Hu proteins family, Drosophila sex-lethal (SXL), and similar proteins
      cd12649
      Location:117 → 197
      RRM1_SXL; RNA recognition motif 1 in Drosophila sex-lethal (SXL) and similar proteins
      TIGR01659
      Location:16 → 346
      sex-lethal; sex-lethal family splicing factor

    13. NM_167113.3 → NP_727163.2  Sex lethal, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727163.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH95
      Conserved Domains (3) summary
      cd12376
      Location:171 → 249
      RRM2_Hu_like; RNA recognition motif 2 in the Hu proteins family, Drosophila sex-lethal (SXL), and similar proteins
      cd12649
      Location:85 → 165
      RRM1_SXL; RNA recognition motif 1 in Drosophila sex-lethal (SXL) and similar proteins
      TIGR01659
      Location:1 → 314
      sex-lethal; sex-lethal family splicing factor

    14. NM_167115.3 → NP_727165.2  Sex lethal, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727165.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH95
      Conserved Domains (3) summary
      cd12376
      Location:171 → 249
      RRM2_Hu_like; RNA recognition motif 2 in the Hu proteins family, Drosophila sex-lethal (SXL), and similar proteins
      cd12649
      Location:85 → 165
      RRM1_SXL; RNA recognition motif 1 in Drosophila sex-lethal (SXL) and similar proteins
      TIGR01659
      Location:1 → 314
      sex-lethal; sex-lethal family splicing factor

    15. NM_001031892.2 → NP_001027063.1  Sex lethal, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027063.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6PBY4, E8NH95
      Conserved Domains (3) summary
      cd12376
      Location:201 → 279
      RRM2_Hu_like; RNA recognition motif 2 in the Hu proteins family, Drosophila sex-lethal (SXL), and similar proteins
      cd12649
      Location:115 → 195
      RRM1_SXL; RNA recognition motif 1 in Drosophila sex-lethal (SXL) and similar proteins
      TIGR01659
      Location:18 → 344
      sex-lethal; sex-lethal family splicing factor

    16. NM_001316622.1 → NP_001303551.1  Sex lethal, isoform AC [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH95
      Conserved Domains (3) summary
      cd12376
      Location:188 → 266
      RRM2_Hu_like; RNA recognition motif 2 in the Hu proteins family, Drosophila sex-lethal (SXL), and similar proteins
      cd12649
      Location:102 → 182
      RRM1_SXL; RNA recognition motif 1 in Drosophila sex-lethal (SXL) and similar proteins
      TIGR01659
      Location:4 → 331
      sex-lethal; sex-lethal family splicing factor

    17. NM_001169218.3 → NP_001162689.1  Sex lethal, isoform AB [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162689.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH95
      Conserved Domains (3) summary
      cd12376
      Location:179 → 257
      RRM2_Hu_like; RNA recognition motif 2 in the Hu proteins family, Drosophila sex-lethal (SXL), and similar proteins
      cd12649
      Location:93 → 173
      RRM1_SXL; RNA recognition motif 1 in Drosophila sex-lethal (SXL) and similar proteins
      TIGR01659
      Location:1 → 322
      sex-lethal; sex-lethal family splicing factor

    18. NM_001031894.1 → NP_001027065.1  Sex lethal, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027065.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V434, A4V435, A4V436, A4V437, C9QP40, D0IQK2, D3PFI6, E1JJI8, E1JJI9, E1JJJ0, E1JJJ2, E1JJJ3, P19339, P19340, Q0KHV2, Q26466, Q2MGN7, Q2MGN8, Q2MGN9, Q2MGP1, Q7KVU6, Q7YZ92, Q8IRQ1, Q99141, Q9TYF5, Q9W3S6
      UniProtKB/TrEMBL
      E8NH95
      Conserved Domains (3) summary
      cd12376
      Location:211 → 289
      RRM2_Hu_like; RNA recognition motif 2 in the Hu proteins family, Drosophila sex-lethal (SXL), and similar proteins
      cd12649
      Location:125 → 205
      RRM1_SXL; RNA recognition motif 1 in Drosophila sex-lethal (SXL) and similar proteins
      TIGR01659
      Location:16 → 354
      sex-lethal; sex-lethal family splicing factor

    19. NM_167118.2 → NP_727168.1  Sex lethal, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727168.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PJB1

    20. NM_001272377.1 → NP_001259306.1  Sex lethal, isoform AA [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259306.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PJB1

    21. NM_001169216.2 → NP_001162687.1  Sex lethal, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162687.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGW6

    22. NM_167110.3 → NP_727160.2  Sex lethal, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727160.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH95
      Conserved Domains (3) summary
      cd12376
      Location:203 → 281
      RRM2_Hu_like; RNA recognition motif 2 in the Hu proteins family, Drosophila sex-lethal (SXL), and similar proteins
      cd12649
      Location:117 → 197
      RRM1_SXL; RNA recognition motif 1 in Drosophila sex-lethal (SXL) and similar proteins
      TIGR01659
      Location:16 → 346
      sex-lethal; sex-lethal family splicing factor

    23. NM_001169219.1 → NP_001162690.1  Sex lethal, isoform T [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162690.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V434, A4V435, A4V436, A4V437, C9QP40, D0IQK2, D3PFI6, E1JJI8, E1JJI9, E1JJJ0, E1JJJ2, E1JJJ3, P19339, P19340, Q0KHV2, Q26466, Q2MGN7, Q2MGN8, Q2MGN9, Q2MGP1, Q7KVU6, Q7YZ92, Q8IRQ1, Q99141, Q9TYF5, Q9W3S6
      UniProtKB/TrEMBL
      E8NH95
      Conserved Domains (3) summary
      cd12376
      Location:211 → 289
      RRM2_Hu_like; RNA recognition motif 2 in the Hu proteins family, Drosophila sex-lethal (SXL), and similar proteins
      cd12649
      Location:125 → 205
      RRM1_SXL; RNA recognition motif 1 in Drosophila sex-lethal (SXL) and similar proteins
      TIGR01659
      Location:16 → 354
      sex-lethal; sex-lethal family splicing factor

    24. NM_001031895.1 → NP_001027066.1  Sex lethal, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027066.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGW6

    25. NM_080052.4 → NP_524791.3  Sex lethal, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524791.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6PBY4, E8NH95
      Conserved Domains (3) summary
      cd12376
      Location:201 → 279
      RRM2_Hu_like; RNA recognition motif 2 in the Hu proteins family, Drosophila sex-lethal (SXL), and similar proteins
      cd12649
      Location:115 → 195
      RRM1_SXL; RNA recognition motif 1 in Drosophila sex-lethal (SXL) and similar proteins
      TIGR01659
      Location:18 → 344
      sex-lethal; sex-lethal family splicing factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PGK6 M9PGK6
    M9PGW6 M9PGW6
    M9PHB3 M9PHB3
    M9PJB1 M9PJB1
    P19339.1 P19339
    Q6SE36 Q6SE36

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