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    BTK Bruton tyrosine kinase [ Gallus gallus (chicken) ]

    Gene ID: 374075, updated on 10-Oct-2024

    Summary

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    Official Symbol
    BTKprovided by CGNC
    Official Full Name
    Bruton tyrosine kinaseprovided by CGNC
    Primary source
    CGNC:3685
    See related
    Ensembl:ENSGALG00010015975
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See BTK in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (1984163..1995856)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (2020642..2032333)

    Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene glycine receptor alpha 4 Neighboring gene galactosidase alpha Neighboring gene ribosomal protein L36a Neighboring gene translocase of inner mitochondrial membrane 8A Neighboring gene magnesium transporter NIPA2-like Neighboring gene TATA-box binding protein associated factor 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression profiling of chicken DT40 lymphoma cells indicates clonal selection of knockout and gene reconstituted cells. Nawaz HM, et al. Biochem Biophys Res Commun, 2008 Dec 12. PMID 18930021
    2. Cloning and functional characterization of chicken stem cell antigen 2. Mao W, et al. Dev Comp Immunol, 2010 Mar. PMID 19945479
    3. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Microarray analysis of SCA-2 induced bursal cells showed BTK to be among the under-expressed genes and this was validated with qRT-PCR.
      Title: Cloning and functional characterization of chicken stem cell antigen 2.
    2. Expression profiling of Btk defective DT40 lymphoma cells
      Title: Expression profiling of chicken DT40 lymphoma cells indicates clonal selection of knockout and gene reconstituted cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in T cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-tyrosine autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein kinase BTK
    Names
    Bruton agammaglobulinemia tyrosine kinase
    NP_989564.2
    XP_015133649.1
    XP_015133650.1
    XP_046771349.1
    XP_046771350.1
    XP_046771351.1
    XP_046771352.1
    XP_046771353.1
    XP_046771354.1
    XP_046771355.1
    XP_046771356.1
    XP_046771357.1
    XP_046771358.1
    XP_046771359.1
    XP_046771360.1
    XP_046771361.1
    XP_046771362.1
    XP_046795789.1
    XP_046795790.1
    XP_046795791.1
    XP_046795792.1
    XP_046795793.1
    XP_046795794.1
    XP_046795795.1
    XP_046795796.1
    XP_046795797.1
    XP_046795798.1
    XP_046795799.1
    XP_046795800.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204233.3 → NP_989564.2  tyrosine-protein kinase BTK

      See identical proteins and their annotated locations for NP_989564.2

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000071
      UniProtKB/Swiss-Prot
      Q8JH64
      UniProtKB/TrEMBL
      Q5ZLF2
      Conserved Domains (6) summary
      cd05113
      Location:395 → 650
      PTKc_Btk_Bmx; Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome
      cd10397
      Location:271 → 377
      SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)
      cd11906
      Location:214 → 268
      SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase
      cd01238
      Location:6 → 165
      PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
      pfam00169
      Location:4 → 132
      PH; PH domain
      pfam07714
      Location:400 → 646
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      1984163..1995856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046939839.1 → XP_046795795.1  tyrosine-protein kinase BTK isoform X4

      UniProtKB/TrEMBL
      Q5ZLF2

    2. XM_046939842.1 → XP_046795798.1  tyrosine-protein kinase BTK isoform X4

      UniProtKB/TrEMBL
      Q5ZLF2

    3. XM_046939843.1 → XP_046795799.1  tyrosine-protein kinase BTK isoform X4

      UniProtKB/TrEMBL
      Q5ZLF2

    4. XM_046939834.1 → XP_046795790.1  tyrosine-protein kinase BTK isoform X4

      UniProtKB/TrEMBL
      Q5ZLF2

    5. XM_046939838.1 → XP_046795794.1  tyrosine-protein kinase BTK isoform X4

      UniProtKB/TrEMBL
      Q5ZLF2

    6. XM_046939840.1 → XP_046795796.1  tyrosine-protein kinase BTK isoform X4

      UniProtKB/TrEMBL
      Q5ZLF2

    7. XM_046939841.1 → XP_046795797.1  tyrosine-protein kinase BTK isoform X4

      UniProtKB/TrEMBL
      Q5ZLF2

    8. XM_046939844.1 → XP_046795800.1  tyrosine-protein kinase BTK isoform X3

    9. XM_015278163.4 → XP_015133649.1  tyrosine-protein kinase BTK isoform X1

      UniProtKB/Swiss-Prot
      Q8JH64
      Conserved Domains (6) summary
      cd05113
      Location:437 → 692
      PTKc_Btk_Bmx; Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome
      cd10397
      Location:313 → 419
      SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)
      cd11906
      Location:256 → 310
      SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase
      cd01238
      Location:48 → 207
      PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
      pfam00169
      Location:46 → 174
      PH; PH domain
      pfam07714
      Location:442 → 688
      Pkinase_Tyr; Protein tyrosine kinase

    10. XM_015278164.4 → XP_015133650.1  tyrosine-protein kinase BTK isoform X2

      UniProtKB/Swiss-Prot
      Q8JH64
      Conserved Domains (6) summary
      cd05113
      Location:436 → 691
      PTKc_Btk_Bmx; Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome
      cd10397
      Location:312 → 418
      SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)
      cd11906
      Location:255 → 309
      SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase
      cd01238
      Location:48 → 206
      PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
      pfam00169
      Location:46 → 173
      PH; PH domain
      pfam07714
      Location:441 → 687
      Pkinase_Tyr; Protein tyrosine kinase

    11. XM_046939836.1 → XP_046795792.1  tyrosine-protein kinase BTK isoform X4

      UniProtKB/TrEMBL
      Q5ZLF2

    12. XM_046939837.1 → XP_046795793.1  tyrosine-protein kinase BTK isoform X4

      UniProtKB/TrEMBL
      Q5ZLF2
      Related
      ENSGALP00010022279.1, ENSGALT00010038503.1

    13. XM_046939835.1 → XP_046795791.1  tyrosine-protein kinase BTK isoform X4

      UniProtKB/TrEMBL
      Q5ZLF2
      Related
      ENSGALP00010022278.1, ENSGALT00010038502.1

    14. XM_046939833.1 → XP_046795789.1  tyrosine-protein kinase BTK isoform X3

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      2020642..2032333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046915402.1 → XP_046771358.1  tyrosine-protein kinase BTK isoform X4

      UniProtKB/TrEMBL
      Q5ZLF2

    2. XM_046915404.1 → XP_046771360.1  tyrosine-protein kinase BTK isoform X4

      UniProtKB/TrEMBL
      Q5ZLF2

    3. XM_046915405.1 → XP_046771361.1  tyrosine-protein kinase BTK isoform X4

      UniProtKB/TrEMBL
      Q5ZLF2

    4. XM_046915396.1 → XP_046771352.1  tyrosine-protein kinase BTK isoform X4

      UniProtKB/TrEMBL
      Q5ZLF2

    5. XM_046915400.1 → XP_046771356.1  tyrosine-protein kinase BTK isoform X4

      UniProtKB/TrEMBL
      Q5ZLF2

    6. XM_046915401.1 → XP_046771357.1  tyrosine-protein kinase BTK isoform X4

      UniProtKB/TrEMBL
      Q5ZLF2

    7. XM_046915403.1 → XP_046771359.1  tyrosine-protein kinase BTK isoform X4

      UniProtKB/TrEMBL
      Q5ZLF2

    8. XM_046915406.1 → XP_046771362.1  tyrosine-protein kinase BTK isoform X3

    9. XM_046915393.1 → XP_046771349.1  tyrosine-protein kinase BTK isoform X1

    10. XM_046915394.1 → XP_046771350.1  tyrosine-protein kinase BTK isoform X2

    11. XM_046915398.1 → XP_046771354.1  tyrosine-protein kinase BTK isoform X4

      UniProtKB/TrEMBL
      Q5ZLF2

    12. XM_046915399.1 → XP_046771355.1  tyrosine-protein kinase BTK isoform X4

      UniProtKB/TrEMBL
      Q5ZLF2

    13. XM_046915397.1 → XP_046771353.1  tyrosine-protein kinase BTK isoform X4

      UniProtKB/TrEMBL
      Q5ZLF2

    14. XM_046915395.1 → XP_046771351.1  tyrosine-protein kinase BTK isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8JH64.1 GenPept UniProtKB/Swiss-Prot:Q8JH64

    Gene LinkOut

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