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    SMN survival of motor neuron [ Gallus gallus (chicken) ]

    Gene ID: 374025, updated on 6-Jun-2024

    Summary

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    Symbol
    SMNprovided by CGNC
    Full Name
    survival of motor neuronprovided by CGNC
    Primary source
    CGNC:49008
    See related
    Ensembl:ENSGALG00010009431
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
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    Genomic context

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    See SMN in Genome Data Viewer
    Location:
    chromosome: Z
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) Z NC_052572.1 (73566072..73571600, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) Z NC_059536.1 (73566072..73571600, complement)

    Chromosome Z - NC_052572.1Genomic Context describing neighboring genes Neighboring gene MARVEL domain containing 2 Neighboring gene general transcription factor IIH subunit 2 Neighboring gene small EDRK-rich factor 1-like Neighboring gene B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A cell system with targeted disruption of the SMN gene: functional conservation of the SMN protein and dependence of Gemin2 on SMN. Wang J, et al. J Biol Chem, 2001 Mar 30. PMID 11121410
    2. Multiprotein complexes of the survival of motor neuron protein SMN with Gemins traffic to neuronal processes and growth cones of motor neurons. Zhang H, et al. J Neurosci, 2006 Aug 16. PMID 16914688, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings provide new insight into the molecular composition of distinct SMN multiprotein complexes in neurons and motivation to investigate deficiencies of localized RNPs in spinal muscular atrophy.
      Title: Multiprotein complexes of the survival of motor neuron protein SMN with Gemins traffic to neuronal processes and growth cones of motor neurons.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    survival motor neuron protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204199.2 → NP_989530.1  survival motor neuron protein

      See identical proteins and their annotated locations for NP_989530.1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000096
      UniProtKB/TrEMBL
      A0A8V0Y601, Q98SU9
      Related
      ENSGALP00010012979.1, ENSGALT00010022534.1
      Conserved Domains (2) summary
      cd04508
      Location:83 → 131
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam06003
      Location:13 → 264
      SMN; Survival motor neuron protein (SMN)

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      73566072..73571600 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015280582.4 → XP_015136068.1  survival motor neuron protein isoform X1

      UniProtKB/TrEMBL
      A0A8V0Y601, Q98SU9
      Conserved Domains (2) summary
      cd04508
      Location:83 → 131
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam06003
      Location:13 → 264
      SMN; Survival motor neuron protein (SMN)

    2. XM_015280581.4 → XP_015136067.1  survival motor neuron protein isoform X1

      UniProtKB/TrEMBL
      A0A8V0Y601, Q98SU9
      Related
      ENSGALP00010012983.1, ENSGALT00010022539.1
      Conserved Domains (2) summary
      cd04508
      Location:83 → 131
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam06003
      Location:13 → 264
      SMN; Survival motor neuron protein (SMN)

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      73566072..73571600 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046934647.1 → XP_046790603.1  survival motor neuron protein isoform X1

      UniProtKB/TrEMBL
      A0A8V0Y601, Q98SU9

    2. XM_046934646.1 → XP_046790602.1  survival motor neuron protein isoform X1

      UniProtKB/TrEMBL
      A0A8V0Y601, Q98SU9
    Nucleotide Protein Strain
    Heading Accession and Version

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