Ermp1 endoplasmic reticulum metallopeptidase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ermp1provided by RGD
Official Full Name: endoplasmic reticulum metallopeptidase 1provided by RGD
Primary source: RGD:727831
See related: EnsemblRapid:ENSRNOG00000010915 AllianceGenome:RGD:727831
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fxna
Summary: Predicted to enable metal ion binding activity and metalloexopeptidase activity. Involved in ovarian follicle development. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human ERMP1 (endoplasmic reticulum metallopeptidase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 287.8), Lung (RPKM 157.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q52

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (236801459..236835656, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (227383992..227422120, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (247784830..247821771, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results suggest that the attenuation of miR-9 on ischemic injury may be involved in targeting ERMP1-mediated ER stress, which provides an available target for Ischemic stroke treatment
Title: miR-9-5p attenuates ischemic stroke through targeting ERMP1-mediated endoplasmic reticulum stress.
Fxna is required for the organization of somatic cells and oocytes into discrete follicular structure. Fxna may facilitate follicular organization by processing precursor proteins required for intraovarian cell-to-cell communication.
Title: Fxna, a novel gene differentially expressed in the rat ovary at the time of folliculogenesis, is required for normal ovarian histogenesis.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH141591 (e-PCR)
- UniSTS:223585

RH142556 (e-PCR)
- UniSTS:231803

RH129587 (e-PCR)
- UniSTS:212886

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloexopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum unfolded protein response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endoplasmic reticulum unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: endoplasmic reticulum metallopeptidase 1

Names: felix-ina; putative aminopeptidase Fxna

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_184050.2 → NP_908939.2 endoplasmic reticulum metallopeptidase 1

See identical proteins and their annotated locations for NP_908939.2

Status: PROVISIONAL

Source sequence(s)

AY364634

UniProtKB/Swiss-Prot

Q6UPR8

UniProtKB/TrEMBL

F1M6W2

Related

ENSRNOP00000105566.1, ENSRNOT00000138939.1

Conserved Domains (1) summary

cd03875
Location:99 → 406

M28_Fxna_like; M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

236801459..236835656 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006231241.5 → XP_006231303.1 endoplasmic reticulum metallopeptidase 1 isoform X1

UniProtKB/TrEMBL

F1M6W2

Conserved Domains (1) summary

cd03875
Location:99 → 406

M28_Fxna_like; M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1