Btk Bruton tyrosine kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Btkprovided by RGD
Official Full Name: Bruton tyrosine kinaseprovided by RGD
Primary source: RGD:1359683
See related: EnsemblRapid:ENSRNOG00000052407 AllianceGenome:RGD:1359683
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein tyrosine kinase activity. Involved in several processes, including positive regulation of gene expression; positive regulation of hypersensitivity; and regulation of B cell activation. Located in perinuclear region of cytoplasm. Used to study arthus reaction. Human ortholog(s) of this gene implicated in agammaglobulinemia (multiple); isolated growth hormone deficiency type III; and lymphoma (multiple). Orthologous to human BTK (Bruton tyrosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 217.2), Thymus (RPKM 46.2) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq32

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (102016070..102055448, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (97722796..97762315, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (105360922..105390580, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of Bruton's Tyrosine Kinase Activity Attenuates Hemorrhagic Shock-Induced Multiple Organ Dysfunction in Rats.
Title: Inhibition of Bruton's Tyrosine Kinase Activity Attenuates Hemorrhagic Shock-Induced Multiple Organ Dysfunction in Rats.
Btk together with PI3-kinase are part of TLR2 multiprotein complex and mediate LTA-induced TLR2 responses in macrophages.
Title: Bruton's tyrosine kinase together with PI 3-kinase are part of Toll-like receptor 2 multiprotein complex and mediate LTA induced Toll-like receptor 2 responses in macrophages.

Submit: New GeneRIF Correction

General gene information

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Markers

AU027485 (e-PCR)
- UniSTS:113260

PMC24278P1 (e-PCR)
- UniSTS:272251

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phospholipase activator activity	ISO Inferred from Sequence Orthology more info
enables phospholipase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell affinity maturation	ISO Inferred from Sequence Orthology more info
involved_in B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to interleukin-7	ISO Inferred from Sequence Orthology more info
involved_in cellular response to molecule of fungal origin	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to reactive oxygen species	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eosinophil homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in histamine secretion by mast cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in monocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of B cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of leukocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immunoglobulin production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-17A production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synoviocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type I hypersensitivity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type III hypersensitivity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in proteoglycan catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tyrosine-protein kinase BTK

Names: Bruton agammaglobulinemia tyrosine kinase

NP_001007799.2

EC 2.7.10.1

XP_038955880.1

EC 2.7.10.1

XP_038955881.1

EC 2.7.10.1

XP_038955882.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007798.2 → NP_001007799.2 tyrosine-protein kinase BTK

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A0G2K6M9, Q5S255

Related

ENSRNOP00000073875.2, ENSRNOT00000086863.3

Conserved Domains (4) summary

cd05113
Location:399 → 654

PTKc_Btk_Bmx; Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome

cd10397
Location:276 → 380

SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)

cd11906
Location:219 → 273

SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase

cd01238
Location:6 → 168

PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

102016070..102055448 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099954.2 → XP_038955882.1 tyrosine-protein kinase BTK isoform X1

UniProtKB/TrEMBL

A0A0G2K6M9, Q5S255

Conserved Domains (4) summary

cd05113
Location:399 → 654

PTKc_Btk_Bmx; Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome

cd10397
Location:276 → 380

SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)

cd11906
Location:219 → 273

SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase

cd01238
Location:6 → 168

PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
XM_039099952.2 → XP_038955880.1 tyrosine-protein kinase BTK isoform X1

UniProtKB/TrEMBL

A0A0G2K6M9, Q5S255

Conserved Domains (4) summary

cd05113
Location:399 → 654

PTKc_Btk_Bmx; Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome

cd10397
Location:276 → 380

SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)

cd11906
Location:219 → 273

SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase

cd01238
Location:6 → 168

PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
XM_039099953.2 → XP_038955881.1 tyrosine-protein kinase BTK isoform X1

UniProtKB/TrEMBL

A0A0G2K6M9, Q5S255

Conserved Domains (4) summary

cd05113
Location:399 → 654

PTKc_Btk_Bmx; Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome

cd10397
Location:276 → 380

SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)

cd11906
Location:219 → 273

SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase

cd01238
Location:6 → 168

PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain