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    Pif1 PIF1 5'-to-3' DNA helicase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367645, updated on 2-Nov-2024

    Summary

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    Symbol
    Pif1provided by RGD
    Full Name
    PIF1 5'-to-3' DNA helicaseprovided by RGD
    Primary source
    RGD:1586053
    See related
    EnsemblRapid:ENSRNOG00000015878 AllianceGenome:RGD:1586053
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including ATP binding activity; helicase activity; and magnesium ion binding activity. Predicted to be involved in several processes, including DNA duplex unwinding; negative regulation of telomere maintenance via telomerase; and protein-DNA-RNA complex disassembly. Predicted to be located in chromosome, telomeric region. Predicted to be active in replication fork. Orthologous to human PIF1 (PIF1 5'-to-3' DNA helicase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 25.8), Thymus (RPKM 18.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pif1 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (75005820..75015331)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (66110641..66120202)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (71124477..71133460)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and death domain containing 1A Neighboring gene pleckstrin homology domain containing O2 Neighboring gene RNA binding protein, mRNA processing factor 2 Neighboring gene uncharacterized LOC103693122 Neighboring gene ornithine decarboxylase antizyme 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Murine Pif1 interacts with telomerase and is dispensable for telomere function in vivo. Snow BE, et al. Mol Cell Biol, 2007 Feb. PMID 17130244, Free PMC Article
    2. The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity. Zhang DH, et al. Nucleic Acids Res, 2006. PMID 16522649, Free PMC Article
    3. Alternative translation initiation augments the human mitochondrial proteome. Kazak L, et al. Nucleic Acids Res, 2013 Feb 1. PMID 23275553, Free PMC Article
    4. Pif1 family helicases suppress genome instability at G-quadruplex motifs. Paeschke K, et al. Nature, 2013 May 23. PMID 23657261, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 5'-3' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-3' DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 5'-3' DNA/RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G-quadruplex DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables telomerase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial genome maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-DNA-RNA complex disassembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein-DNA-RNA complex disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent DNA helicase PIF1
    Names
    DNA repair and recombination helicase PIF1
    PIF1/RRM3 DNA helicase-like protein
    Pif1/Rrm3 DNA-helicase-like protein
    NP_001037718.1
    XP_038937819.1
    XP_038937820.1
    XP_063122010.1
    XP_063122011.1
    XP_063122012.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044253.1 → NP_001037718.1  ATP-dependent DNA helicase PIF1

      See identical proteins and their annotated locations for NP_001037718.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ489562
      UniProtKB/Swiss-Prot
      Q1HG60
      Conserved Domains (2) summary
      pfam02689
      Location:547 → 594
      Herpes_Helicase; Helicase
      cl21455
      Location:202 → 500
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      75005820..75015331
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081892.2 → XP_038937820.1  ATP-dependent DNA helicase PIF1 isoform X4

      Conserved Domains (1) summary
      cd18037
      Location:206 → 377
      DEXSc_Pif1_like; DEAD-box helicase domain of Pif1

    2. XM_039081891.2 → XP_038937819.1  ATP-dependent DNA helicase PIF1 isoform X3

      Conserved Domains (1) summary
      cd18037
      Location:206 → 377
      DEXSc_Pif1_like; DEAD-box helicase domain of Pif1

    3. XM_063265941.1 → XP_063122011.1  ATP-dependent DNA helicase PIF1 isoform X1

    4. XM_063265940.1 → XP_063122010.1  ATP-dependent DNA helicase PIF1 isoform X1

    5. XM_063265942.1 → XP_063122012.1  ATP-dependent DNA helicase PIF1 isoform X2

      UniProtKB/Swiss-Prot
      Q1HG60
      Related
      ENSRNOP00000021265.6, ENSRNOT00000021265.7

    RNA

    1. XR_010054012.1 RNA Sequence

    2. XR_005487883.2 RNA Sequence

    3. XR_005487882.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1HG60.1 GenPept UniProtKB/Swiss-Prot:Q1HG60

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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