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    Mgat4a alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367252, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mgat4aprovided by RGD
    Official Full Name
    alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Aprovided by RGD
    Primary source
    RGD:1305650
    See related
    EnsemblRapid:ENSRNOG00000018276 AllianceGenome:RGD:1305650
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable alanine-glyoxylate transaminase activity; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity; and protein homodimerization activity. Predicted to be involved in N-glycan processing; glyoxylate metabolic process; and protein N-linked glycosylation. Predicted to be located in peroxisome. Predicted to be active in Golgi stack; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human MGAT4A (alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 166.4), Kidney (RPKM 105.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mgat4a in Genome Data Viewer
    Location:
    9q21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (47169229..47282577, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (39673427..39786747, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (44033433..44126946, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate-4-phosphatase type I A Neighboring gene uncharacterized LOC120094669 Neighboring gene cytochrome C oxidase assembly factor 5 Neighboring gene unc-50 inner nuclear membrane RNA binding protein Neighboring gene CRACD like Neighboring gene uncharacterized LOC134480567 Neighboring gene U2 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. HCV affects K(ATP) channels through GnT-IVa-mediated N-glycosylation of GLUT2 on the surface of pancreatic β-cells leading to impaired insulin secretion. Niu B, et al. Endocrine, 2024 May. PMID 37962815, Free PMC Article
    2. Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer. Ide Y, et al. Biochem Biophys Res Commun, 2006 Mar 10. PMID 16434023
    3. Physiological and glycomic characterization of N-acetylglucosaminyltransferase-IVa and -IVb double deficient mice. Takamatsu S, et al. Glycobiology, 2010 Jan. PMID 20015870, Free PMC Article
    4. The absence of core fucose up-regulates GnT-III and Wnt target genes: a possible mechanism for an adaptive response in terms of glycan function. Kurimoto A, et al. J Biol Chem, 2014 Apr 25. PMID 24619415, Free PMC Article
    5. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HCV affects KATP channels through GnT-IVa-mediated N-glycosylation of GLUT2 on the surface of pancreatic beta-cells leading to impaired insulin secretion.
      Title: HCV affects K(ATP) channels through GnT-IVa-mediated N-glycosylation of GLUT2 on the surface of pancreatic β-cells leading to impaired insulin secretion.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alanine-glyoxylate transaminase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glycosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N-glycan processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in glyoxylate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi stack IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
    Names
    N-acetylglucosaminyltransferase IVa
    N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa
    UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa
    glcNAc-T IVa
    gnT-IVa
    mannoside acetylglucosaminyltransferase 4, isoenzyme A
    mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
    NP_001012225.1
    NP_001153627.1
    XP_006244902.1
    XP_017452062.1
    XP_038939898.1
    XP_038939899.1
    XP_063123578.1
    XP_063123579.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012225.2 → NP_001012225.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform 2

      See identical proteins and their annotated locations for NP_001012225.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal 10-aa segment, compared to isoform 1.
      Source sequence(s)
      BC088215, BM388934, JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q5M854
      UniProtKB/TrEMBL
      A6INH4
      Related
      ENSRNOP00000095476.1, ENSRNOT00000097529.2
      Conserved Domains (1) summary
      pfam04666
      Location:94 → 371
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

    2. NM_001160155.1 → NP_001153627.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC088215, BM388934, CV115746, JAXUCZ010000009
      UniProtKB/TrEMBL
      A6INH4, F1LMP1
      Related
      ENSRNOP00000024701.5, ENSRNOT00000024701.8
      Conserved Domains (2) summary
      pfam04666
      Location:103 → 380
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
      cd21105
      Location:287 → 302
      PGAP4-like; putative TM2 helix [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      47169229..47282577 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267508.1 → XP_063123578.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X3

      UniProtKB/Swiss-Prot
      Q5M854

    2. XM_063267509.1 → XP_063123579.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X4

    3. XM_039083970.2 → XP_038939898.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X1

      UniProtKB/TrEMBL
      A6INH4, F1LMP1
      Related
      ENSRNOP00000101140.1, ENSRNOT00000138713.1
      Conserved Domains (2) summary
      pfam04666
      Location:103 → 380
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
      cd21105
      Location:287 → 302
      PGAP4-like; putative TM2 helix [structural motif]

    4. XM_006244840.4 → XP_006244902.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X2

      UniProtKB/TrEMBL
      A6INH4
      Conserved Domains (1) summary
      pfam04666
      Location:103 → 380
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

    5. XM_017596573.3 → XP_017452062.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X1

      UniProtKB/TrEMBL
      A6INH4, F1LMP1
      Conserved Domains (2) summary
      pfam04666
      Location:103 → 380
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
      cd21105
      Location:287 → 302
      PGAP4-like; putative TM2 helix [structural motif]

    6. XM_039083971.2 → XP_038939899.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X1

      UniProtKB/TrEMBL
      A6INH4, F1LMP1
      Conserved Domains (2) summary
      pfam04666
      Location:103 → 380
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
      cd21105
      Location:287 → 302
      PGAP4-like; putative TM2 helix [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5M854.1 GenPept UniProtKB/Swiss-Prot:Q5M854

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