Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pik3cdprovided by RGD
Official Full Name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit deltaprovided by RGD
Primary source: RGD:1310990
See related: EnsemblRapid:ENSRNOG00000016846 AllianceGenome:RGD:1310990
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in negative regulation of gene expression. Predicted to be located in cytosol. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA. Predicted to be active in cytoplasm and plasma membrane. Used to study schizophrenia. Human ortholog(s) of this gene implicated in colorectal cancer; endometrial cancer; immunodeficiency 14; and schizophrenia. Orthologous to human PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 363.9), Thymus (RPKM 286.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (165377994..165426620, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (160094952..160142962, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (166602053..166628028, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of SEMP1 Contributes to Improving the Biological Functions of Trophoblast via the PI3K/AKT Pathway in Preeclampsia.
Title: Upregulation of SEMP1 Contributes to Improving the Biological Functions of Trophoblast via the PI3K/AKT Pathway in Preeclampsia.
Inhibition of mitochondrial fission alters neo-intimal hyperplasia via PI3K/Akt signaling in arteriovenous fistulas.
Title: Inhibition of mitochondrial fission alters neo-intimal hyperplasia via PI3K/Akt signaling in arteriovenous fistulas.
BAFF/BAFF-R involved in autoantibody production in rats with collagen-induced arthritis via PI3K-Akt-mTOR signaling and the regulation of paeoniflorin.
Title: BAFF/BAFF-R involved in antibodies production of rats with collagen-induced arthritis via PI3K-Akt-mTOR signaling and the regulation of paeoniflorin.

Submit: New GeneRIF Correction

General gene information

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Markers

RH142729 (e-PCR)
- UniSTS:231976

BE109926 (e-PCR)
- UniSTS:248382

RH133425 (e-PCR)
- UniSTS:216708

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IEA Inferred from Electronic Annotation more info
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within B cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to fungus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homeostasis of number of cells	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial tube formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
part_of phosphatidylinositol 3-kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class IA	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Names: catalytic phosphatidylinositol 3-kinase delta; phosphatidylinositol 3-kinase catalytic delta polypeptide; phosphoinositide-3-kinase, catalytic, delta polypeptide

NP_001102448.1

EC 2.7.1.153

XP_038966422.1

EC 2.7.1.153

XP_038966423.1

EC 2.7.1.153

XP_038966424.1

EC 2.7.1.153

XP_038966425.1

EC 2.7.1.153

XP_038966426.1

EC 2.7.1.153

XP_038966427.1

EC 2.7.1.153

XP_038966428.1

EC 2.7.1.153

XP_038966429.1

EC 2.7.1.153

XP_038966430.1

EC 2.7.1.153

XP_038966431.1

EC 2.7.1.153

XP_038966432.1

EC 2.7.1.153

XP_038966433.1

EC 2.7.1.153

XP_063144203.1

EC 2.7.1.153

XP_063144204.1

EC 2.7.1.153

XP_063144205.1

EC 2.7.1.153

XP_063144206.1

EC 2.7.1.153

XP_063144207.1

EC 2.7.1.153

XP_063144208.1

EC 2.7.1.153

XP_063144209.1

EC 2.7.1.153

XP_063144210.1

EC 2.7.1.153

XP_063144211.1

EC 2.7.1.153

XP_063144212.1

EC 2.7.1.153

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108978.1 → NP_001102448.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

See identical proteins and their annotated locations for NP_001102448.1

Status: PROVISIONAL

Source sequence(s)

CH473968

UniProtKB/TrEMBL

A6IUB9, D4A5Q1

Related

ENSRNOP00000061674.2, ENSRNOT00000066179.4

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:507 → 628

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain

cl21453
Location:620 → 942

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

165377994..165426620 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063288141.1 → XP_063144211.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X9
XM_039110505.2 → XP_038966433.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X8

Conserved Domains (5) summary

cd08693
Location:308 → 475

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:498 → 681

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:673 → 1040

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 275

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_039110504.2 → XP_038966432.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X7

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:505 → 683

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:675 → 1041

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_039110501.2 → XP_038966429.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X4

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:505 → 686

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:678 → 1044

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_039110500.2 → XP_038966428.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:505 → 686

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:678 → 1045

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_039110503.2 → XP_038966431.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X6

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:504 → 684

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:676 → 1042

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_039110502.2 → XP_038966430.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:504 → 684

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:676 → 1043

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_039110499.2 → XP_038966427.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2

UniProtKB/TrEMBL

A0A8I5Y949

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:504 → 687

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:679 → 1045

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_039110494.2 → XP_038966422.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:504 → 687

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:679 → 1046

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_063288133.1 → XP_063144203.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1
XM_063288137.1 → XP_063144207.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5
XM_039110495.2 → XP_038966423.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:504 → 687

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:679 → 1046

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_063288138.1 → XP_063144208.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X6
XM_039110496.2 → XP_038966424.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:504 → 687

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:679 → 1046

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_063288136.1 → XP_063144206.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2

UniProtKB/TrEMBL

A0A8I5Y949
XM_063288140.1 → XP_063144210.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X6
XM_039110498.2 → XP_038966426.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:504 → 687

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:679 → 1046

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_039110497.2 → XP_038966425.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:504 → 687

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:679 → 1046

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_063288142.1 → XP_063144212.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X9
XM_063288134.1 → XP_063144204.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2

UniProtKB/TrEMBL

A0A8I5Y949
XM_063288139.1 → XP_063144209.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X6
XM_063288135.1 → XP_063144205.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2

UniProtKB/TrEMBL

A0A8I5Y949

Related

ENSRNOP00000076811.1, ENSRNOT00000095643.2