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    Coq4 coenzyme Q4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366013, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Coq4provided by RGD
    Official Full Name
    coenzyme Q4provided by RGD
    Primary source
    RGD:1304638
    See related
    EnsemblRapid:ENSRNOG00000026691 AllianceGenome:RGD:1304638
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be part of ubiquinone biosynthesis complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 7 and spastic ataxia. Orthologous to human COQ4 (coenzyme Q4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 73.1), Kidney (RPKM 61.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Coq4 in Genome Data Viewer
    Location:
    3p12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (33457834..33468387)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (13060054..13070502)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (8349386..8357719)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486066 Neighboring gene TruB pseudouridine synthase family member 2 Neighboring gene solute carrier family 27 member 4 Neighboring gene ubiquitin related modifier 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of the human COQ5 C-methyltransferase in coenzyme Q10 biosynthesis. Nguyen TP, et al. Biochim Biophys Acta, 2014 Nov. PMID 25152161, Free PMC Article
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116264

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in ubiquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquinone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquinone biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in extrinsic component of mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquinone biosynthesis complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquinone biosynthesis protein COQ4 homolog, mitochondrial
    Names
    coenzyme Q biosynthesis protein 4 homolog
    coenzyme Q4 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031662.1 → NP_001026832.1  ubiquinone biosynthesis protein COQ4 homolog, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001026832.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099123
      UniProtKB/Swiss-Prot
      Q4FZU1
      Related
      ENSRNOP00000038869.4, ENSRNOT00000038602.7
      Conserved Domains (1) summary
      pfam05019
      Location:62 → 258
      Coq4; Coenzyme Q (ubiquinone) biosynthesis protein Coq4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      33457834..33468387
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284260.1 → XP_063140330.1  ubiquinone biosynthesis protein COQ4 homolog, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHW2, A6JTS3

    2. XM_039105582.2 → XP_038961510.1  ubiquinone biosynthesis protein COQ4 homolog, mitochondrial isoform X2

      Conserved Domains (1) summary
      pfam05019
      Location:66 → 213
      Coq4; Coenzyme Q (ubiquinone) biosynthesis protein Coq4

    RNA

    1. XR_010064672.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4FZU1.1 GenPept UniProtKB/Swiss-Prot:Q4FZU1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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