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    Trim55 tripartite motif-containing 55 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365751, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Trim55provided by RGD
    Official Full Name
    tripartite motif-containing 55provided by RGD
    Primary source
    RGD:1306943
    See related
    EnsemblRapid:ENSRNOG00000012723 AllianceGenome:RGD:1306943
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rnf29
    Summary
    Predicted to enable identical protein binding activity; protein-macromolecule adaptor activity; and ubiquitin protein ligase activity. Predicted to be involved in innate immune response; positive regulation of non-canonical NF-kappaB signal transduction; and protein K48-linked ubiquitination. Predicted to act upstream of or within with a positive effect on diapedesis and leukocyte migration involved in inflammatory response. Predicted to act upstream of or within with a negative effect on macrophage migration. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human TRIM55 (tripartite motif containing 55). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 516.3) and Muscle (RPKM 225.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trim55 in Genome Data Viewer
    Location:
    2q24
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (104016361..104058302)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (102100229..102142173)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (104416972..104459117)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene transfer RNA tyrosine (anticodon GUA) 8 Neighboring gene transfer RNA tyrosine (anticodon GUA) 2 Neighboring gene uncharacterized LOC120100781 Neighboring gene corticotropin releasing hormone Neighboring gene CCR4-NOT transcription complex, subunit 8, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Muscle-specific RING finger-2 (MURF-2) is important for microtubule, intermediate filament and sarcomeric M-line maintenance in striated muscle development. McElhinny AS, et al. J Cell Sci, 2004 Jul 1. PMID 15199100
    2. miR-378a-3p inhibits ischemia/reperfusion-induced apoptosis in H9C2 cardiomyocytes by targeting TRIM55 via the DUSP1-JNK1/2 signaling pathway. Tan J, et al. Aging (Albany NY), 2020 May 28. PMID 32463795, Free PMC Article
    3. Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross. Gralinski LE, et al. PLoS Genet, 2015 Oct. PMID 26452100, Free PMC Article
    4. [Translocation of MuRF isoforms to nuclei in postural muscle during gravitational unloading]. Lomonosova IuN, et al. Ross Fiziol Zh Im I M Sechenova, 2015 Jan. PMID 25868327
    5. Transient association of titin and myosin with microtubules in nascent myofibrils directed by the MURF2 RING-finger protein. Pizon V, et al. J Cell Sci, 2002 Dec 1. PMID 12414993

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-378a-3p inhibits ischemia/reperfusion-induced apoptosis in H9C2 cardiomyocytes by targeting TRIM55 via the DUSP1-JNK1/2 signaling pathway.
      Title: miR-378a-3p inhibits ischemia/reperfusion-induced apoptosis in H9C2 cardiomyocytes by targeting TRIM55 via the DUSP1-JNK1/2 signaling pathway.
    2. MuRF1 and MuRF2 translocate to the nuclei in the soleus muscle during gravitational unloading.
      Title: [Translocation of MuRF isoforms to nuclei in postural muscle during gravitational unloading].
    3. Neonatal rat cardiomyocytes expressing MURF2+3 specific siRNA have reduced expression of both MURF2 and -3
      Title: Developmental regulation of MURF ubiquitin ligases and autophagy proteins nbr1, p62/SQSTM1 and LC3 during cardiac myofibril assembly and turnover.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in diapedesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within_positive_effect diapedesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leukocyte migration involved in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within_positive_effect leukocyte migration involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in macrophage migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within_negative_effect macrophage migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tripartite motif-containing protein 55
    Names
    MURF-2
    muRF2
    muscle-specific RING finger protein 2
    ring finger protein 29
    NP_001012218.1
    XP_006232243.1
    XP_006232244.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012218.1 → NP_001012218.1  tripartite motif-containing protein 55

      See identical proteins and their annotated locations for NP_001012218.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087100
      UniProtKB/Swiss-Prot
      Q5PQN5
      UniProtKB/TrEMBL
      A0A8L2UJ67, A6IHB9
      Related
      ENSRNOP00000017125.7, ENSRNOT00000017125.7
      Conserved Domains (3) summary
      cd16760
      Location:21 → 84
      RING-HC_MuRF2; RING finger, HC subclass, found in muscle-specific RING finger protein 2 (MuRF-2) and similar proteins
      cd19832
      Location:122 → 166
      Bbox2_MuRF2_C-II; B-box-type 2 zinc finger found in muscle-specific RING finger protein 2 (MuRF-2) and similar proteins
      pfam06160
      Location:158 → 323
      EzrA; Septation ring formation regulator, EzrA

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      104016361..104058302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232181.4 → XP_006232243.1  tripartite motif-containing protein 55 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZNU7, A0A8I6A0E8
      Related
      ENSRNOP00000084028.1, ENSRNOT00000094830.2
      Conserved Domains (3) summary
      cd00162
      Location:26 → 85
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam00643
      Location:120 → 161
      zf-B_box; B-box zinc finger
      cl23765
      Location:168 → 294
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    2. XM_006232182.4 → XP_006232244.1  tripartite motif-containing protein 55 isoform X2

      UniProtKB/TrEMBL
      A0A8L2UJ67
      Conserved Domains (3) summary
      cd00162
      Location:26 → 85
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam00643
      Location:120 → 161
      zf-B_box; B-box zinc finger
      cl23765
      Location:168 → 294
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PQN5.1 GenPept UniProtKB/Swiss-Prot:Q5PQN5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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