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    Zbtb24 zinc finger and BTB domain containing 24 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365590, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zbtb24provided by RGD
    Official Full Name
    zinc finger and BTB domain containing 24provided by RGD
    Primary source
    RGD:1306951
    See related
    EnsemblRapid:ENSRNOG00000000308 AllianceGenome:RGD:1306951
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bif1a; ZNF450
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 2. Orthologous to human ZBTB24 (zinc finger and BTB domain containing 24). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 37.0), Spleen (RPKM 26.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zbtb24 in Genome Data Viewer
    Location:
    20q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (46525982..46546363)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (44943302..44965329)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (46168149..46189806)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene UTP15, small subunit processome component Neighboring gene adenylate kinase 9 Neighboring gene uncharacterized LOC120098942 Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing 1 Neighboring gene sphingomyelin phosphodiesterase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Bone morphogenetic protein-2 induces expression of murine zinc finger transcription factor ZNF450. Edgar AJ, et al. J Cell Biochem, 2005 Jan 1. PMID 15526281
    2. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in hematopoietic progenitor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 24
    Names
    bone morphogenetic protein-induced factor 1
    zinc finger protein 450

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098667.2 → NP_001092137.2  zinc finger and BTB domain-containing protein 24

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A8L2QRY7, A6K719
      Related
      ENSRNOP00000054002.4, ENSRNOT00000057175.4
      Conserved Domains (5) summary
      COG5048
      Location:320 → 479
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:407 → 427
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18212
      Location:14 → 130
      BTB_POZ_ZBTB24_ZNF450; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24)
      pfam13465
      Location:477 → 500
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:295 → 339
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      46525982..46546363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098907.2 → XP_038954835.1  zinc finger and BTB domain-containing protein 24 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QRY7, A6K719
      Conserved Domains (5) summary
      COG5048
      Location:320 → 479
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:407 → 427
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18212
      Location:14 → 130
      BTB_POZ_ZBTB24_ZNF450; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24)
      pfam13465
      Location:477 → 500
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:295 → 339
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    2. XM_063279330.1 → XP_063135400.1  zinc finger and BTB domain-containing protein 24 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3B725.1 GenPept UniProtKB/Swiss-Prot:Q3B725

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