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    Mical2 microtubule associated monooxygenase, calponin and LIM domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365352, updated on 2-Nov-2024

    Summary

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    Symbol
    Mical2provided by RGD
    Full Name
    microtubule associated monooxygenase, calponin and LIM domain containing 2provided by RGD
    Primary source
    RGD:1311773
    See related
    EnsemblRapid:ENSRNOG00000016210 EnsemblRapid:ENSRNOG00000079050 AllianceGenome:RGD:1311773
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mical-2; Micalcl; RSB-11-77; RGD1311773
    Summary
    Predicted to enable several functions, including FAD binding activity; NAD(P)H oxidase H2O2-forming activity; and mitogen-activated protein kinase binding activity. Predicted to be involved in several processes, including actin filament depolymerization; heart looping; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Predicted to be active in actin filament. Orthologous to human MICAL2 (microtubule associated monooxygenase, calponin and LIM domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 171.4), Brain (RPKM 152.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mical2 in Genome Data Viewer
    Location:
    1q33
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (175780441..175965157)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (166345853..166530575)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (177048607..177173729)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 47 Neighboring gene dickkopf WNT signaling pathway inhibitor 3 Neighboring gene parvin, alpha Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Actin stimulates reduction of the MICAL-2 monooxygenase domain. McDonald CA, et al. Biochemistry, 2013 Sep 3. PMID 23927065
    2. Molecular cloning of Ebitein1: a novel extracellular signal-regulated kinase 2-binding protein in testis. Miura K, et al. Biochem Biophys Res Commun, 2008 Apr 4. PMID 18241670
    3. MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the rat. Pasterkamp RJ, et al. Mol Cell Neurosci, 2006 Jan. PMID 16230022
    4. Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Lundby A, et al. Nat Commun, 2012 Jun 6. PMID 22673903, Free PMC Article
    5. MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation. Lee BC, et al. Mol Cell, 2013 Aug 8. PMID 23911929, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tesults implicate MICALs in neuronal regeneration and support the possibility to attenuate axon repulsion in the injured spinal cord.
      Title: MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the rat.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112586, MGC114239

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables F-actin monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables NAD(P)H oxidase H2O2-forming activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD(P)H oxidase H2O2-forming activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitogen-activated protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitogen-activated protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mitogen-activated protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament depolymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin filament depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament depolymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in heart looping ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sulfur oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfur oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sulfur oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in actin filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in actin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    [F-actin]-monooxygenase MICAL2; F-actin-monooxygenase MICAL2
    Names
    ERK2-binding testicular protein 1
    MICAL C-terminal like
    MICAL C-terminal-like protein
    [F-actin]-methionine sulfoxide oxidase MICAL2
    ebitein-1
    mical-cL
    molecule interacting with CasL protein 2
    protein MICAL-2
    protein-methionine sulfoxide oxidase MICAL2
    NP_001132980.1
    NP_001382794.1
    NP_872610.2
    XP_063125450.1
    XP_063125453.1
    XP_063125459.1
    XP_063125462.1
    XP_063125464.1
    XP_063125466.1
    XP_063125469.1
    XP_063125474.1
    XP_063125481.1
    XP_063125483.1
    XP_063125486.1
    XP_063125489.1
    XP_063125490.1
    XP_063125494.1
    XP_063125499.1
    XP_063125501.1
    XP_063125506.1
    XP_063125511.1
    XP_063125512.1
    XP_063125515.1
    XP_063125516.1
    XP_063125520.1
    XP_063125525.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001139508.2 → NP_001132980.1  [F-actin]-monooxygenase MICAL2 isoform 2

      See identical proteins and their annotated locations for NP_001132980.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I5ZXM8, A6I861
      Conserved Domains (3) summary
      cd09439
      Location:754 → 808
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam01494
      Location:87 → 274
      FAD_binding_3; FAD binding domain
      cd21250
      Location:514 → 623
      CH_MICAL2; calponin homology (CH) domain found in molecule interacting with CasL protein 2

    2. NM_001395865.1 → NP_001382794.1  [F-actin]-monooxygenase MICAL2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      D4A1F2, F1LW55, Q498N8, Q4G091, Q80WN5
      Conserved Domains (5) summary
      cd09439
      Location:754 → 808
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      smart00033
      Location:520 → 617
      CH; Calponin homology domain
      PHA03247
      Location:826 → 983
      PHA03247; large tegument protein UL36; Provisional
      cl30692
      Location:87 → 224
      UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]
      pfam17380
      Location:1509 → 1673
      DUF5401; Family of unknown function (DUF5401)

    3. NM_182669.2 → NP_872610.2  [F-actin]-monooxygenase MICAL2 isoform 3

      See identical proteins and their annotated locations for NP_872610.2

      Status: PROVISIONAL

      Source sequence(s)
      BC098647
      UniProtKB/TrEMBL
      A6I864
      Related
      ENSRNOP00000039759.5, ENSRNOT00000043017.6
      Conserved Domains (1) summary
      pfam12130
      Location:535 → 673
      DUF3585; Protein of unknown function (DUF3585)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      175780441..175965157
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269404.1 → XP_063125474.1  F-actin-monooxygenase MICAL2 isoform X4

    2. XM_063269413.1 → XP_063125483.1  F-actin-monooxygenase MICAL2 isoform X6

    3. XM_063269416.1 → XP_063125486.1  F-actin-monooxygenase MICAL2 isoform X7

    4. XM_063269380.1 → XP_063125450.1  F-actin-monooxygenase MICAL2 isoform X1

    5. XM_063269396.1 → XP_063125466.1  F-actin-monooxygenase MICAL2 isoform X2

    6. XM_063269399.1 → XP_063125469.1  F-actin-monooxygenase MICAL2 isoform X3

    7. XM_063269455.1 → XP_063125525.1  F-actin-monooxygenase MICAL2 isoform X15

    8. XM_063269383.1 → XP_063125453.1  F-actin-monooxygenase MICAL2 isoform X1

    9. XM_063269389.1 → XP_063125459.1  F-actin-monooxygenase MICAL2 isoform X1

    10. XM_063269392.1 → XP_063125462.1  F-actin-monooxygenase MICAL2 isoform X1

    11. XM_063269420.1 → XP_063125490.1  F-actin-monooxygenase MICAL2 isoform X9

    12. XM_063269419.1 → XP_063125489.1  F-actin-monooxygenase MICAL2 isoform X8

    13. XM_063269431.1 → XP_063125501.1  F-actin-monooxygenase MICAL2 isoform X10

    14. XM_063269446.1 → XP_063125516.1  F-actin-monooxygenase MICAL2 isoform X13

    15. XM_063269441.1 → XP_063125511.1  F-actin-monooxygenase MICAL2 isoform X12

    16. XM_063269424.1 → XP_063125494.1  F-actin-monooxygenase MICAL2 isoform X9

    17. XM_063269436.1 → XP_063125506.1  F-actin-monooxygenase MICAL2 isoform X11

      UniProtKB/TrEMBL
      A0A8I6AIG9
      Related
      ENSRNOP00000093313.1, ENSRNOT00000102148.2

    18. XM_063269445.1 → XP_063125515.1  F-actin-monooxygenase MICAL2 isoform X12

    19. XM_063269429.1 → XP_063125499.1  F-actin-monooxygenase MICAL2 isoform X9

      Related
      ENSRNOP00000074877.1, ENSRNOT00000081595.3

    20. XM_063269450.1 → XP_063125520.1  F-actin-monooxygenase MICAL2 isoform X14

    21. XM_063269411.1 → XP_063125481.1  F-actin-monooxygenase MICAL2 isoform X5

    22. XM_063269394.1 → XP_063125464.1  F-actin-monooxygenase MICAL2 isoform X1

    23. XM_063269442.1 → XP_063125512.1  F-actin-monooxygenase MICAL2 isoform X12

    RNA

    1. XR_010055211.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D4A1F2.2 GenPept UniProtKB/Swiss-Prot:D4A1F2

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