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    Rnase1l1 ribonuclease, RNase A family, 1-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364303, updated on 25-Jul-2024

    Summary

    Official Symbol
    Rnase1l1provided by RGD
    Official Full Name
    ribonuclease, RNase A family, 1-like 1provided by RGD
    Primary source
    RGD:1310106
    See related
    EnsemblRapid:ENSRNOG00000025615 AllianceGenome:RGD:1310106
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rac1; RNase 1; Rnase1d
    Summary
    Predicted to enable ribonuclease activity. Predicted to be involved in RNA phosphodiester bond hydrolysis. Predicted to act upstream of or within response to bacterium. Predicted to be located in extracellular region. Orthologous to human RNASE1 (ribonuclease A family member 1, pancreatic). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 150.4) and Liver (RPKM 61.0) See more
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    Genomic context

    See Rnase1l1 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (26811738..26813456, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (24338216..24339934, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (28043491..28045098, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene transfer RNA proline (anticodon UGG) 6 Neighboring gene ribonuclease A family member 4 Neighboring gene angiogenin Neighboring gene epididymal protein 3B Neighboring gene histone H3.3A-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA nuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribonuclease A activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ribonuclease pancreatic delta-type
    Names
    RNase 1 delta
    pancreatic ribonuclease delta
    ribonuclease A c1
    ribonuclease, RNase A family, 1-like 1 (pancreatic)
    XP_006251955.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013232.2NP_001013250.2  ribonuclease pancreatic delta-type precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      26811738..26813456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251893.3XP_006251955.1  ribonuclease pancreatic delta-type isoform X1

      See identical proteins and their annotated locations for XP_006251955.1

      UniProtKB/TrEMBL
      F1M5W9, W0UVC8
      Related
      ENSRNOP00000105058.1, ENSRNOT00000121684.1
      Conserved Domains (1) summary
      smart00092
      Location:31150
      RNAse_Pc; Pancreatic ribonuclease