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    PRA1 Pra1p [ Candida albicans SC5314 ]

    Gene ID: 3642969, updated on 30-Nov-2023

    Summary

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    Gene symbol
    PRA1
    Gene description
    Pra1p
    Locus tag
    CAALFM_C406980WA
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Candida albicans SC5314 (strain: SC5314, nat-host: Homo sapiens, culture-collection: ATCC:MYA-2876)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida
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    Genomic context

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    See PRA1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    1
    Sequence:
    Chromosome: 4; NC_032092.1 (1547130..1548029)

    Chromosome 4 - NC_032092.1Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Zrt1p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_032092.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of pH-regulated antigen 1 of Candida albicans in the fungal recognition and antifungal response of human neutrophils. Losse J, et al. Mol Immunol, 2011 Sep. PMID 21820180
    2. Analysis of PRA1 and its relationship to Candida albicans- macrophage interactions. Marcil A, et al. Infect Immun, 2008 Sep. PMID 18625733, Free PMC Article
    3. The secreted Candida albicans protein Pra1 disrupts host defense by broadly targeting and blocking complement C3 and C3 activation fragments. Luo S, et al. Mol Immunol, 2018 Jan. PMID 28860090
    4. Secreted pH-regulated antigen 1 of Candida albicans blocks activation and conversion of complement C3. Luo S, et al. J Immunol, 2010 Aug 15. PMID 20644161
    5. Regulation of innate immune response to Candida albicans infections by αMβ2-Pra1p interaction. Soloviev DA, et al. Infect Immun, 2011 Apr. PMID 21245270, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pra1 is a hierarchical complement inhibitor that targets C3 by cleaving C3 at a unique site. This inhibited effector function of the activation fragments. Pra1 also bound to C3a and C3b generated by human convertases and blocked their effector functions, C3a binding to human C3a receptor, calcium signaling, IL-8 release, C3b deposition, opsonophagocytosis, and killing by neutrophils.
      Title: The secreted Candida albicans protein Pra1 disrupts host defense by broadly targeting and blocking complement C3 and C3 activation fragments.
    2. surface-exposed Pra1 plays a role in the recognition of Candida albicans, especially hyphal cells, by human neutrophils
      Title: Role of pH-regulated antigen 1 of Candida albicans in the fungal recognition and antifungal response of human neutrophils.
    3. recognition of pH-regulated antigen 1 protein (Pra1p) by integrin alpha(M)betaplays a pivotal role in determining fungal virulence and host response and protection against C. albicans infection
      Title: Regulation of innate immune response to Candida albicans infections by αMβ2-Pra1p interaction.
    4. Data show that the fungus secretes a potent complement inhibitor, pH-regulated Ag 1 (Pra1), which in the direct surrounding of the pathogen binds to fluid-phase C3 and blocks cleavage of C3 to C3a and C3b.
      Title: Secreted pH-regulated antigen 1 of Candida albicans blocks activation and conversion of complement C3.
    5. The pH-regulated antigen 1 (Pra1) protein was identified as a novel Factor H and FHL-1 binding protein.
      Title: Immune evasion of the human pathogenic yeast Candida albicans: Pra1 is a Factor H, FHL-1 and plasminogen binding surface protein.
    6. Therefore, it appears that Pra1p can play at most a minor role in fibrinogen binding to C. albicans.
      Title: Analysis of PRA1 and its relationship to Candida albicans- macrophage interactions.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in fungal-type cell wall IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Pra1p
    XP_715420.2
    • Cell surface protein that sequesters zinc from host tissue; enriched at hyphal tips; released extracellularly; binds to host complement regulators; mediates leukocyte adhesion and migration; immunogenic in mouse; produced at ambient pH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_032092.1 Reference assembly

      Range
      1547130..1548029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_710327.2 → XP_715420.2  Pra1p [Candida albicans SC5314]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      A0A1D8PMQ8, P78598, P87020, Q5A0Y5, Q5A156
      UniProtKB/TrEMBL
      C4YGF4
      Conserved Domains (1) summary
      pfam13933
      Location:4 → 241
      HRXXH; Putative peptidase family
    Nucleotide Protein
    Heading Accession and Version

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