vg vestigial [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: vgprovided by FlyBase
Official Full Name: vestigialprovided by FlyBase
Primary source: FLYBASE:FBgn0003975
Locus tag: Dmel_CG3830
See related: AllianceGenome:FB:FBgn0003975
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3830; Dmel\CG3830; Vg; VG; vg21
Summary: Enables transcription coactivator activity. Involved in several processes, including determination of muscle attachment site; imaginal disc pattern formation; and imaginal disc-derived appendage development. Located in nucleus. Is expressed in several structures, including cuboidal/columnar epithelium; dorsal thoracic disc; ganglia; larval somatic muscle cell; and somatic precursor cell. Orthologous to several human genes including VGLL2 (vestigial like family member 2). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: all
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Genomic context

Location:: 49E1-49E1; 2-67 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (12884201..12899385)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (8772137..8786890)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vestigial-dependent induction contributes to robust patterning but is not essential for wing-fate recruitment in Drosophila.
Title: Vestigial-dependent induction contributes to robust patterning but is not essential for wing-fate recruitment in Drosophila.
A cis-regulatory sequence of the selector gene vestigial drives the evolution of wing scaling in Drosophila species.
Title: A cis-regulatory sequence of the selector gene vestigial drives the evolution of wing scaling in Drosophila species.
Vestigial suppresses apoptosis and cell migration in a manner dependent on the level of JNK-Caspase signaling in the Drosophila wing disc.
Title: Vestigial suppresses apoptosis and cell migration in a manner dependent on the level of JNK-Caspase signaling in the Drosophila wing disc.
Study shows that Polycomb Response Elements (PREs) near the wing selector gene vestigial have distinctive roles at their endogenous locus, even though both PREs are repressors in transgenes. First, a PRE near the promoter is required for vestigial activation and not for repression. Second, only the distal PRE contributes to H3K27me3, but even removal of both PREs does not eliminate H3K27me3 across the vestigial domain.
Title: Separate Polycomb Response Elements control chromatin state and activation of the vestigial gene.
Vestigial protein phosphorylation of serine 215 occurs in the nucleus and requires the presence of Scalloped.
Title: The activity of the Drosophila Vestigial protein is modified by Scalloped-dependent phosphorylation.
here we examine the interactions between Msk and the Wg pathway in regulation of the AMP pool size. We find that a myoblast-specific reduction of Msk results in the absence of Vg expression and a complete loss of the Wg pathway readout beta-catenin/Armadillo (Arm). Moreover, msk RNA interference knockdown abolishes expression of the Wg target Ladybird (Lbe) in leg disc myoblasts.
Title: Adult Muscle Formation Requires Drosophila Moleskin for Proliferation of Wing Disc-Associated Muscle Precursors.
High hydrostatic pressure-induced wing mutagenesis in Drosophila melanogaster resulted in 285 differentially expressed genes and two point mutations in the vestigial gene.
Title: Molecular Mechanisms for High Hydrostatic Pressure-Induced Wing Mutagenesis in Drosophila melanogaster.
Data show that genes araucan and caupolican as novel muscle identity genes that confer lateral transverse muscle identity, and the acquisition of this fate requires that Araucan/Caupolican repress other muscle identity genes such as slouch and vestigial.
Title: Drosophila araucan and caupolican integrate intrinsic and signalling inputs for the acquisition by muscle progenitors of the lateral transverse fate.
Studies indicate that negative regulation of the Vestigial gradient by Wingless signaling makes vestigial expression precise and robust.
Title: Spatiotemporally modulated Vestigial gradient by Wingless signaling adaptively regulates cell division for precise wing size control.
Vg is a key factor to induce specific changes in ventral longitudinal muscles 1-4 identity and is required for these cells to be competent to form stable intermuscular attachments with each other.
Title: Vestigial is required during late-stage muscle differentiation in Drosophila melanogaster embryos.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell elongation involved in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of muscle attachment site	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral lineage restriction, imaginal disc	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in haltere development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc proximal/distal pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: vestigial

Names: CG3830-PA; CG3830-PB; vestgial; vestigal; vg-PA; vg-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

12884201..12899385

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001414091.1 → NP_001401005.1 vestigial, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q26366, Q9V6H9
NM_078999.4 → NP_523723.1 vestigial, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523723.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q26366, Q9V6H9

Related

FBpp0086898

Conserved Domains (1) summary

pfam07545
Location:282 → 312

Vg_Tdu; Vestigial/Tondu family