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    Cnnm4 cyclin and CBS domain divalent metal cation transport mediator 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363216, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cnnm4provided by RGD
    Official Full Name
    cyclin and CBS domain divalent metal cation transport mediator 4provided by RGD
    Primary source
    RGD:1305571
    See related
    EnsemblRapid:ENSRNOG00000015886 AllianceGenome:RGD:1305571
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable magnesium ion transmembrane transporter activity and sodium ion transmembrane transporter activity. Predicted to be involved in intracellular monoatomic cation homeostasis; magnesium ion homeostasis; and magnesium ion transport. Predicted to act upstream of or within enamel mineralization. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in Jalili syndrome. Orthologous to human CNNM4 (cyclin and CBS domain divalent metal cation transport mediator 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 71.5), Kidney (RPKM 53.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cnnm4 in Genome Data Viewer
    Location:
    9q21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (46207602..46246817)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (38711726..38750942)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (43049587..43088690)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene fer-1-like family member 5 Neighboring gene lectin, mannose-binding 2-like Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 3 Neighboring gene ankyrin repeat domain 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Basolateral Mg2+ extrusion via CNNM4 mediates transcellular Mg2+ transport across epithelia: a mouse model. Yamazaki D, et al. PLoS Genet, 2013. PMID 24339795, Free PMC Article
    2. Physical interaction and functional coupling between ACDP4 and the intracellular ion chaperone COX11, an implication of the role of ACDP4 in essential metal ion transport and homeostasis. Guo D, et al. Mol Pain, 2005 Apr 19. PMID 15840172, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables magnesium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in enamel mineralization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within enamel mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular monoatomic cation homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular monoatomic cation homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in magnesium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in magnesium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within magnesium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in magnesium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in magnesium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within magnesium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    metal transporter CNNM4
    Names
    ancient conserved domain-containing protein 4
    cyclin-M4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271050.1 → NP_001257979.1  metal transporter CNNM4 precursor

      See identical proteins and their annotated locations for NP_001257979.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      P0C588
      UniProtKB/TrEMBL
      A6IND6
      Related
      ENSRNOP00000021434.4, ENSRNOT00000021434.9
      Conserved Domains (3) summary
      COG0517
      Location:371 → 498
      CBS; CBS domain [Signal transduction mechanisms]
      cd04590
      Location:380 → 500
      CBS_pair_CorC_HlyC_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in ...
      pfam01595
      Location:194 → 356
      DUF21; Domain of unknown function DUF21

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      46207602..46246817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017596510.3 → XP_017451999.1  metal transporter CNNM4 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYC2, A6IND6
      Related
      ENSRNOP00000070598.2, ENSRNOT00000079234.3

    2. XM_039083840.2 → XP_038939768.1  metal transporter CNNM4 isoform X2

      UniProtKB/TrEMBL
      A6IND6
      Conserved Domains (1) summary
      COG1253
      Location:194 → 521
      TlyC; Hemolysin or related protein, contains CBS domains [General function prediction only]

    3. XM_006244827.5 → XP_006244889.2  metal transporter CNNM4 isoform X3

      UniProtKB/TrEMBL
      A6IND6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C588.1 GenPept UniProtKB/Swiss-Prot:P0C588

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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