Os9 OS9, endoplasmic reticulum lectin [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Os9provided by RGD
Full Name: OS9, endoplasmic reticulum lectinprovided by RGD
Primary source: RGD:1359574
See related: EnsemblRapid:ENSRNOG00000025570 AllianceGenome:RGD:1359574
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Os-9
Summary: Enables protease binding activity. Involved in protein targeting. Located in endoplasmic reticulum lumen. Orthologous to human OS9 (OS9 endoplasmic reticulum lectin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 272.9), Liver (RPKM 258.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (64802517..64829185, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (62915498..62957591, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (70378625..70407135, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIF-1alpha, procollagen-proline dioxygenases and OS-9 are all involved in the pathogenesis of hypoxic pulmonary hypertension in rats.
Title: [The cooperation of OS-9 and PHDs in hypoxia-induced pulmonary hypertension of rats].
characterized alternatively spliced form and found that only the non-spliced form binds to meprin beta, suggesting the possible mechanism of the regulation of OS-9 function.
Title: A selective interaction between OS-9 and the carboxyl-terminal tail of meprin beta.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Os9 (e-PCR), detects polymorphism
- UniSTS:546909

RH127553 (e-PCR)
- UniSTS:210863

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ERAD pathway	IEA Inferred from Electronic Annotation more info
involved_in ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in ERAD pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum unfolded protein response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of retrograde protein transport, ER to cytosol	ISO Inferred from Sequence Orthology more info
involved_in protein retention in ER lumen	ISO Inferred from Sequence Orthology more info
involved_in protein retention in ER lumen	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein targeting	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in retrograde protein transport, ER to cytosol	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum lumen	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum lumen	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein OS-9

Names: amplified in osteosarcoma; osteosarcoma amplified 9, endoplasmic reticulum lectin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007265.1 → NP_001007266.1 protein OS-9 precursor

See identical proteins and their annotated locations for NP_001007266.1

Status: PROVISIONAL

Source sequence(s)

BC085907

UniProtKB/Swiss-Prot

Q5RKH6

UniProtKB/TrEMBL

A0A8I5ZYZ9

Related

ENSRNOP00000044914.2, ENSRNOT00000049895.5

Conserved Domains (1) summary

pfam07915
Location:110 → 181

PRKCSH; Glucosidase II beta subunit-like protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

64802517..64829185 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006241461.2 → XP_006241523.1 protein OS-9 isoform X1

UniProtKB/TrEMBL

A0A8I5ZYZ9, A0A8I6GKC0

Related

ENSRNOP00000093535.2, ENSRNOT00000117544.2

Conserved Domains (1) summary

pfam07915
Location:110 → 181

PRKCSH; Glucosidase II beta subunit-like protein