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    Marchf2 membrane associated ring-CH-type finger 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362849, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Marchf2provided by RGD
    Official Full Name
    membrane associated ring-CH-type finger 2provided by RGD
    Primary source
    RGD:1306395
    See related
    EnsemblRapid:ENSRNOG00000007769 AllianceGenome:RGD:1306395
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    March2; RNF172; MARCH-II; RGD1306395
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in defense response to symbiont; positive regulation of lysosomal protein catabolic process; and protein ubiquitination. Predicted to be located in several cellular components, including Golgi membrane; cytosol; and endoplasmic reticulum. Orthologous to human MARCHF2 (membrane associated ring-CH-type finger 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 846.5), Heart (RPKM 578.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Marchf2 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (15183931..15209988, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (14480605..14507821, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (18559301..18585351, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093540 Neighboring gene zinc finger protein 414 Neighboring gene PML-RARA regulated adaptor molecule 1 Neighboring gene heterogeneous nuclear ribonucleoprotein M Neighboring gene RAB11B, member RAS oncogene family Neighboring gene ribosomal protein lateral stalk subunit P1 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MARCH-III Is a novel component of endosomes with properties similar to those of MARCH-II. Fukuda H, et al. J Biochem, 2006 Jan. PMID 16428329
    2. MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking. Nakamura N, et al. Mol Biol Cell, 2005 Apr. PMID 15689499, Free PMC Article
    3. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. Bartee E, et al. J Virol, 2004 Feb. PMID 14722266, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in antibacterial innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antibacterial innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antiviral innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of lysosomal protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of lysosomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in suppression of viral release by host IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in suppression of viral release by host ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MARCHF2
    Names
    E3 ubiquitin-protein ligase MARCH2
    RING finger protein 172
    RING-type E3 ubiquitin transferase MARCH2
    RING-type E3 ubiquitin transferase MARCHF2
    membrane associated RING-CH finger protein II
    membrane-associated RING finger protein 2
    membrane-associated RING-CH protein II
    membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
    syntaxin-6-binding protein
    NP_001029280.1
    XP_006241188.1
    XP_006241189.1
    XP_008763423.1
    XP_038935345.1
    XP_063119824.1
    XP_063119825.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034108.1 → NP_001029280.1  E3 ubiquitin-protein ligase MARCHF2

      See identical proteins and their annotated locations for NP_001029280.1

      Status: VALIDATED

      Source sequence(s)
      AI578941, BC088286
      UniProtKB/Swiss-Prot
      Q5I0I2
      UniProtKB/TrEMBL
      A0A8I6AGT0, A6KQH7
      Conserved Domains (2) summary
      pfam00558
      Location:173 → 224
      Vpu; Vpu protein
      cd16808
      Location:62 → 113
      RING_CH-C4HC3_MARCH2; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH2 (MARCH2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      15183931..15209988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008765201.4 → XP_008763423.1  E3 ubiquitin-protein ligase MARCHF2 isoform X4

      Conserved Domains (1) summary
      smart00744
      Location:63 → 110
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    2. XM_006241126.4 → XP_006241188.1  E3 ubiquitin-protein ligase MARCHF2 isoform X2

      Related
      ENSRNOP00000010399.6, ENSRNOT00000010399.9
      Conserved Domains (1) summary
      smart00744
      Location:63 → 110
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    3. XM_006241127.5 → XP_006241189.1  E3 ubiquitin-protein ligase MARCHF2 isoform X3

      Conserved Domains (1) summary
      smart00744
      Location:63 → 110
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    4. XM_039079417.2 → XP_038935345.1  E3 ubiquitin-protein ligase MARCHF2 isoform X1

      Conserved Domains (1) summary
      cd16808
      Location:62 → 113
      RING_CH-C4HC3_MARCH2; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH2 (MARCH2)

    5. XM_063263754.1 → XP_063119824.1  E3 ubiquitin-protein ligase MARCHF2 isoform X5

    6. XM_063263755.1 → XP_063119825.1  E3 ubiquitin-protein ligase MARCHF2 isoform X6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001012196.2: Suppressed sequence

      Description
      NM_001012196.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5I0I2.1 GenPept UniProtKB/Swiss-Prot:Q5I0I2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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