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    Zfyve21 zinc finger FYVE-type containing 21 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362789, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zfyve21provided by RGD
    Official Full Name
    zinc finger FYVE-type containing 21provided by RGD
    Primary source
    RGD:1311036
    See related
    EnsemblRapid:ENSRNOG00000012185 AllianceGenome:RGD:1311036
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metal ion binding activity. Predicted to be located in endosome and focal adhesion. Orthologous to human ZFYVE21 (zinc finger FYVE-type containing 21). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 193.0), Lung (RPKM 171.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfyve21 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (136695132..136715601)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (130873979..130894618)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (136380968..136400810)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene kinesin light chain 1 Neighboring gene uncharacterized LOC134479261 Neighboring gene X-ray repair cross complementing 3 Neighboring gene protein phosphatase 1, regulatory subunit 13B Neighboring gene UPF0235 protein C15orf40 homolog Neighboring gene atherin-like Neighboring gene uncharacterized LOC120103629 Neighboring gene uncharacterized LOC134479260

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger FYVE domain-containing protein 21
    Names
    zinc finger, FYVE domain containing 21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108725.2 → NP_001102195.1  zinc finger FYVE domain-containing protein 21 isoform 2

      See identical proteins and their annotated locations for NP_001102195.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AFN3, A6KBT7
      Related
      ENSRNOP00000092004.2, ENSRNOT00000094351.2
      Conserved Domains (2) summary
      cd15727
      Location:38 → 101
      FYVE_ZF21; FYVE domain found in zinc finger FYVE domain-containing protein 21 (ZF21) and similar proteins
      pfam16696
      Location:108 → 223
      ZFYVE21_C; Zinc finger FYVE domain-containing protein 21 C-terminus

    2. NM_001399738.1 → NP_001386667.1  zinc finger FYVE domain-containing protein 21 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      D3ZVP7

    3. NM_001399739.1 → NP_001386668.1  zinc finger FYVE domain-containing protein 21 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      Conserved Domains (2) summary
      cd15727
      Location:38 → 101
      FYVE_ZF21; FYVE domain found in zinc finger FYVE domain-containing protein 21 (ZF21) and similar proteins
      pfam16696
      Location:108 → 228
      ZFYVE21_C; Zinc finger FYVE domain-containing protein 21 C-terminus

    4. NM_001399740.1 → NP_001386669.1  zinc finger FYVE domain-containing protein 21 isofrm 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    RNA

    1. NR_174344.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      136695132..136715601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594237.3 → XP_017449726.1  zinc finger FYVE domain-containing protein 21 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AAK3

    2. XM_063262148.1 → XP_063118218.1  zinc finger FYVE domain-containing protein 21 isoform X6

    3. XM_063262149.1 → XP_063118219.1  zinc finger FYVE domain-containing protein 21 isoform X7

      Related
      ENSRNOP00000090894.1, ENSRNOT00000097439.2

    4. XM_017594236.2 → XP_017449725.1  zinc finger FYVE domain-containing protein 21 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K9E1
      Related
      ENSRNOP00000074963.2, ENSRNOT00000082914.3
      Conserved Domains (2) summary
      cd15727
      Location:38 → 101
      FYVE_ZF21; FYVE domain found in zinc finger FYVE domain-containing protein 21 (ZF21) and similar proteins
      pfam16696
      Location:108 → 247
      ZFYVE21_C; Zinc finger FYVE domain-containing protein 21 C-terminus

    5. XM_017594235.3 → XP_017449724.1  zinc finger FYVE domain-containing protein 21 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K9E1

    6. XM_006240639.5 → XP_006240701.3  zinc finger FYVE domain-containing protein 21 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K9E1

    7. XM_006240641.5 → XP_006240703.3  zinc finger FYVE domain-containing protein 21 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K9E1
      Conserved Domains (2) summary
      cd15727
      Location:38 → 101
      FYVE_ZF21; FYVE domain found in zinc finger FYVE domain-containing protein 21 (ZF21) and similar proteins
      pfam16696
      Location:108 → 246
      ZFYVE21_C; Zinc finger FYVE domain-containing protein 21 C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZVP7.1 GenPept UniProtKB/Swiss-Prot:D3ZVP7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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