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    Faap20 FA core complex associated protein 20 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362678, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Faap20provided by RGD
    Official Full Name
    FA core complex associated protein 20provided by RGD
    Primary source
    RGD:1308923
    See related
    EnsemblRapid:ENSRNOG00000036876 AllianceGenome:RGD:1308923
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308923
    Summary
    Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and ubiquitin-modified protein reader activity. Predicted to be involved in interstrand cross-link repair and translesion synthesis. Predicted to be located in cell junction; chromatin; and nuclear body. Predicted to be part of Fanconi anaemia nuclear complex. Orthologous to human FAAP20 (FA core complex associated protein 20). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 48.4), Adrenal (RPKM 32.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Faap20 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171083328..171097599)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (165808370..165815291)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (172648171..172655576)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene Ski proto-oncogene Neighboring gene uncharacterized LOC103692526 Neighboring gene protein kinase C, zeta Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class P, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair. Leung JW, et al. Proc Natl Acad Sci U S A, 2012 Mar 20. PMID 22396592, Free PMC Article
    2. Regulation of Rev1 by the Fanconi anemia core complex. Kim H, et al. Nat Struct Mol Biol, 2012 Jan 22. PMID 22266823, Free PMC Article
    3. FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway. Ali AM, et al. Blood, 2012 Apr 5. PMID 22343915, Free PMC Article
    4. A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network. Yan Z, et al. Mol Cell, 2012 Jul 13. PMID 22705371, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables K63-linked polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables K63-linked polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables K63-linked polyubiquitin modification-dependent protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables polyubiquitin modification-dependent protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-modified protein reader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-modified protein reader activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in interstrand cross-link repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interstrand cross-link repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translesion synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translesion synthesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Fanconi anaemia nuclear complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Fanconi anaemia nuclear complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Fanconi anaemia nuclear complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Fanconi anemia core complex-associated protein 20
    Names
    FANCA-associated protein of 20 kDa
    Fanconi anemia core complex associated protein 20
    Fanconi anemia-associated protein of 20 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108698.1 → NP_001102168.1  Fanconi anemia core complex-associated protein 20

      See identical proteins and their annotated locations for NP_001102168.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473968
      UniProtKB/Swiss-Prot
      D4AAA5
      UniProtKB/TrEMBL
      A0A8I6GGQ9
      Conserved Domains (2) summary
      pfam15750
      Location:151 → 182
      UBZ_FAAP20; Ubiquitin-binding zinc-finger
      pfam15751
      Location:34 → 142
      FANCA_interact; FAAP20 FANCA interaction domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      171083328..171097599
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239585.5 → XP_006239647.1  Fanconi anemia core complex-associated protein 20 isoform X1

      Related
      ENSRNOP00000088935.2, ENSRNOT00000108872.2
      Conserved Domains (2) summary
      pfam15750
      Location:212 → 243
      UBZ_FAAP20; Ubiquitin-binding zinc-finger
      pfam15751
      Location:95 → 203
      FANCA_interact; FAAP20 FANCA interaction domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D4AAA5.1 GenPept UniProtKB/Swiss-Prot:D4AAA5

    Gene LinkOut

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